Expression of KCTD14 in cancer - Summary

GENERAL INFORMATION
Gene name	KCTD14
Gene description	Potassium channel tetramerization domain containing 14
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Hep G2, RPTEC TERT1, U-2 OS)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including seminal vesicle and adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA041118 , HPA042181
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable), renal cancer (favourable), pancreatic cancer (unfavourable), thyroid cancer (favourable) and ovarian cancer (favourable).
Melanoma p<0.001 Renal cancer p<0.001 Pancreatic cancer p<0.001 Thyroid cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041118	HPA042181

GENE INFORMATION
Gene name	KCTD14 (HGNC Symbol)
Synonyms	MGC2376
Description	Potassium channel tetramerization domain containing 14 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q14.1
Chromosome location (bp)	78015715 - 78046191
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151364 (version 83.38)
Entrez gene	65987
UniProt	Q9BQ13 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ13
Antibodypedia	KCTD14 antibodies

PROTEIN BROWSER

KCTD14-001	KCTD14-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCTD14-001 ENSP00000316482 ENST00000353172	Q9BQ13 [Direct mapping] BTB/POZ domain-containing protein KCTD14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0051260 [protein homooligomerization] Show all	255 aa 29.6 kDa	No	0
KCTD14-002 ENSP00000431155 ENST00000533144	Q9BQ13 [Direct mapping] BTB/POZ domain-containing protein KCTD14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0051260 [protein homooligomerization] Show all	225 aa 26.2 kDa	No	0