Cell atlas - AKR1C2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AKR1C2
Gene description	Aldo-keto reductase family 1, member C2
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & cytosol. In addition localized to the endoplasmic reticulum & nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (Hep G2, A549, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Cytosol (approved)
Additional location	In addition localized to the Nucleoli fibrillar center (approved), Endoplasmic reticulum (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA068265
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, A549, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & cytosol. In addition localized to the endoplasmic reticulum & nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleus (approved), Cytosol (approved)

Additional location

Nucleoli fibrillar center (approved), Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA068265	A549	Nucleus	Spatial
		Nucleoli fibrillar center	Spatial
		Endoplasmic reticulum
		Cytosol	Spatial
HPA068265	Hep G2	Nucleus	Spatial
		Nucleoli fibrillar center
		Endoplasmic reticulum
		Cytosol	Spatial
HPA068265	U-2 OS	Nucleoli fibrillar center

GENE INFORMATION
Gene name	AKR1C2 (HGNC Symbol)
Synonyms	BABP, DD, DD2, DDH2, HAKRD, MCDR2, TDD
Description	Aldo-keto reductase family 1, member C2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	10
Cytoband	p15.1
Chromosome location (bp)	4922564 - 5135226
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151632 (version 83.38)
Entrez gene	1646
UniProt	P52895 (UniProt - Evidence at protein level)
neXtProt	NX_P52895
Antibodypedia	AKR1C2 antibodies

PROTEIN BROWSER

AKR1C2-001	AKR1C2-003	AKR1C2-007	AKR1C2-201	AKR1C2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKR1C2-001 ENSP00000370129 ENST00000380753	P52895 [Direct mapping] Aldo-keto reductase family 1 member C2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004032 [alditol:NADP+ 1-oxidoreductase activity] GO:0005737 [cytoplasm] GO:0006693 [prostaglandin metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007586 [digestion] GO:0008202 [steroid metabolic process] GO:0008284 [positive regulation of cell proliferation] GO:0016491 [oxidoreductase activity] GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor] GO:0018636 [phenanthrene 9,10-monooxygenase activity] GO:0030855 [epithelial cell differentiation] GO:0031406 [carboxylic acid binding] GO:0032052 [bile acid binding] GO:0042448 [progesterone metabolic process] GO:0044597 [daunorubicin metabolic process] GO:0044598 [doxorubicin metabolic process] GO:0047086 [ketosteroid monooxygenase activity] GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055114 [oxidation-reduction process] GO:0071395 [cellular response to jasmonic acid stimulus] GO:0071799 [cellular response to prostaglandin D stimulus] Show all	323 aa 36.7 kDa	No	0
AKR1C2-003 ENSP00000392694 ENST00000421196	B4DK69 [Direct mapping] Aldo-keto reductase family 1 member C2; cDNA FLJ52680, highly similar to Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	297 aa 33.8 kDa	No	0
AKR1C2-007 ENSP00000474566 ENST00000604507	S4R3P0 [Direct mapping] Aldo-keto reductase family 1 member C2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	200 aa 22.6 kDa	No	0
AKR1C2-201 ENSP00000385221 ENST00000407674	A0A0A0MSD5 [Direct mapping] Aldo-keto reductase family 1 member C2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	323 aa 36.8 kDa	No	0
AKR1C2-202 ENSP00000408440 ENST00000455190	P52895 [Direct mapping] Aldo-keto reductase family 1 member C2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004032 [alditol:NADP+ 1-oxidoreductase activity] GO:0005737 [cytoplasm] GO:0006693 [prostaglandin metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007586 [digestion] GO:0008202 [steroid metabolic process] GO:0008284 [positive regulation of cell proliferation] GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor] GO:0018636 [phenanthrene 9,10-monooxygenase activity] GO:0030855 [epithelial cell differentiation] GO:0031406 [carboxylic acid binding] GO:0032052 [bile acid binding] GO:0042448 [progesterone metabolic process] GO:0044597 [daunorubicin metabolic process] GO:0044598 [doxorubicin metabolic process] GO:0047086 [ketosteroid monooxygenase activity] GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055114 [oxidation-reduction process] GO:0071395 [cellular response to jasmonic acid stimulus] GO:0071799 [cellular response to prostaglandin D stimulus] Show all	139 aa 15.7 kDa	No	0