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AKR1C2

GENERAL INFORMATION

Gene name

 AKR1C2

Gene description

 Aldo-keto reductase family 1, member C2

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, liver cancer, lung cancer, urothelial cancer)
HPA (cell line):Cell line enhanced (A549, Hep G2, RT4)
HPA (normal tissue):Group enriched (adipose tissue, breast, esophagus, gallbladder, liver, stomach, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most prominent in urinary bladder, intestinal tract and liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB047304
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, liver cancer, lung cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB047304

GENE INFORMATION

Gene name

 AKR1C2 (HGNC Symbol)

Synonyms

 BABP, DD, DD2, DDH2, HAKRD, MCDR2, TDD

Description

 Aldo-keto reductase family 1, member C2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 4922564 - 5135226

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151632 (version 83.38)

Entrez gene

 1646

UniProt

 P52895 (UniProt - Evidence at protein level)

neXtProt

 NX_P52895

Antibodypedia

 AKR1C2 antibodies

PROTEIN BROWSER
AKR1C2-001
AKR1C2-003
AKR1C2-007
AKR1C2-201
AKR1C2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1C2-001
ENSP00000370129
ENST00000380753
P52895 [Direct mapping]
Aldo-keto reductase family 1 member C2
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0005737 [cytoplasm]
GO:0006693 [prostaglandin metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007586 [digestion]
GO:0008202 [steroid metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018636 [phenanthrene 9,10-monooxygenase activity]
GO:0030855 [epithelial cell differentiation]
GO:0031406 [carboxylic acid binding]
GO:0032052 [bile acid binding]
GO:0042448 [progesterone metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0047086 [ketosteroid monooxygenase activity]
GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055114 [oxidation-reduction process]
GO:0071395 [cellular response to jasmonic acid stimulus]
GO:0071799 [cellular response to prostaglandin D stimulus]
Show all
 323 aa
36.7 kDa 		No 0
AKR1C2-003
ENSP00000392694
ENST00000421196
B4DK69 [Direct mapping]
Aldo-keto reductase family 1 member C2; cDNA FLJ52680, highly similar to Aldo-keto reductase family 1 member C2 (EC 1.-.-.-)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 297 aa
33.8 kDa 		No 0
AKR1C2-007
ENSP00000474566
ENST00000604507
S4R3P0 [Direct mapping]
Aldo-keto reductase family 1 member C2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 200 aa
22.6 kDa 		No 0
AKR1C2-201
ENSP00000385221
ENST00000407674
A0A0A0MSD5 [Direct mapping]
Aldo-keto reductase family 1 member C2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 323 aa
36.8 kDa 		No 0
AKR1C2-202
ENSP00000408440
ENST00000455190
P52895 [Direct mapping]
Aldo-keto reductase family 1 member C2
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0005737 [cytoplasm]
GO:0006693 [prostaglandin metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007586 [digestion]
GO:0008202 [steroid metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018636 [phenanthrene 9,10-monooxygenase activity]
GO:0030855 [epithelial cell differentiation]
GO:0031406 [carboxylic acid binding]
GO:0032052 [bile acid binding]
GO:0042448 [progesterone metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0047086 [ketosteroid monooxygenase activity]
GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055114 [oxidation-reduction process]
GO:0071395 [cellular response to jasmonic acid stimulus]
GO:0071799 [cellular response to prostaglandin D stimulus]
Show all
 139 aa
15.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.