Cell atlas - KCNJ1 - The Human Protein Atlas

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KCNJ1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	KCNJ1
Gene description	Potassium channel, inwardly rectifying subfamily J, member 1
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	KCNJ1 (HGNC Symbol)
Synonyms	Kir1.1, ROMK1
Description	Potassium channel, inwardly rectifying subfamily J, member 1 (HGNC Symbol)
Entrez gene summary	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q24.3
Chromosome location (bp)	128836315 - 128867373
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151704 (version 83.38)
Entrez gene	3758
UniProt	P48048 (UniProt - Evidence at protein level)
neXtProt	NX_P48048
Antibodypedia	KCNJ1 antibodies

PROTEIN BROWSER

KCNJ1-001	KCNJ1-002	KCNJ1-003	KCNJ1-004	KCNJ1-005	KCNJ1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ1-001 ENSP00000316233 ENST00000324036	P48048 [Direct mapping] ATP-sensitive inward rectifier potassium channel 1 A0A024R3K6 [Target identity:100%; Query identity:100%] Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_a Show all	Transporters Transporter channels and pores Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005524 [ATP binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007588 [excretion] GO:0008076 [voltage-gated potassium channel complex] GO:0010107 [potassium ion import] GO:0015272 [ATP-activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	372 aa 42.7 kDa	No	2
KCNJ1-002 ENSP00000316136 ENST00000324003	A0A0C4DFP9 [Direct mapping] ATP-sensitive inward rectifier potassium channel 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0010107 [potassium ion import] GO:0015272 [ATP-activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	139 aa 16.3 kDa	No	1
KCNJ1-003 ENSP00000406320 ENST00000440599	P48048 [Direct mapping] ATP-sensitive inward rectifier potassium channel 1 A0A024R3K6 [Target identity:100%; Query identity:100%] Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_a Show all	Transporters Transporter channels and pores Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005524 [ATP binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007588 [excretion] GO:0008076 [voltage-gated potassium channel complex] GO:0010107 [potassium ion import] GO:0015272 [ATP-activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	372 aa 42.7 kDa	No	2
KCNJ1-004 ENSP00000376432 ENST00000392664	P48048 [Direct mapping] ATP-sensitive inward rectifier potassium channel 1 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0001822 [kidney development] GO:0001894 [tissue homeostasis] GO:0005242 [inward rectifier potassium channel activity] GO:0005524 [ATP binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007588 [excretion] GO:0008076 [voltage-gated potassium channel complex] GO:0009791 [post-embryonic development] GO:0010107 [potassium ion import] GO:0015272 [ATP-activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0034765 [regulation of ion transmembrane transport] GO:0035864 [response to potassium ion] GO:0042277 [peptide binding] GO:0043066 [negative regulation of apoptotic process] GO:0070294 [renal sodium ion absorption] GO:0071286 [cellular response to magnesium ion] GO:0072358 [cardiovascular system development] GO:1900128 [regulation of G-protein activated inward rectifier potassium channel activity] Show all	391 aa 44.8 kDa	No	2
KCNJ1-005 ENSP00000376433 ENST00000392665	P48048 [Direct mapping] ATP-sensitive inward rectifier potassium channel 1 A0A024R3K6 [Target identity:100%; Query identity:100%] Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_a Show all	Transporters Transporter channels and pores Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005524 [ATP binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007588 [excretion] GO:0008076 [voltage-gated potassium channel complex] GO:0010107 [potassium ion import] GO:0015272 [ATP-activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	372 aa 42.7 kDa	No	2
KCNJ1-201 ENSP00000376434 ENST00000392666	P48048 [Direct mapping] ATP-sensitive inward rectifier potassium channel 1 A0A024R3K6 [Target identity:100%; Query identity:100%] Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_a Show all	Transporters Transporter channels and pores Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005524 [ATP binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007588 [excretion] GO:0008076 [voltage-gated potassium channel complex] GO:0010107 [potassium ion import] GO:0015272 [ATP-activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	372 aa 42.7 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.