Cell atlas - PABPC3 - The Human Protein Atlas

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PABPC3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	PABPC3
Gene description	Poly(A) binding protein, cytoplasmic 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (U-266/84)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA045423 , HPA067156
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (U-266/84) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA045423	A-431	Cytosol
HPA045423	U-2 OS	Cytosol
HPA045423	U-251 MG	Cytosol
HPA067156	A-431	Cytosol
HPA067156	RT4	Cytosol
HPA067156	U-2 OS	Cytosol

GENE INFORMATION
Gene name	PABPC3 (HGNC Symbol)
Synonyms	PABP3, PABPL3, tPABP
Description	Poly(A) binding protein, cytoplasmic 3 (HGNC Symbol)
Entrez gene summary	Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]
Chromosome	13
Cytoband	q12.13
Chromosome location (bp)	25095868 - 25099254
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151846 (version 83.38)
Entrez gene	5042
UniProt	Q9H361 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H361
Antibodypedia	PABPC3 antibodies

PROTEIN BROWSER

PABPC3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PABPC3-001 ENSP00000281589 ENST00000281589	Q9H361 [Direct mapping] Polyadenylate-binding protein 3 Q5VX58 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] GO:0008143 [poly(A) binding] GO:0016071 [mRNA metabolic process] GO:0070062 [extracellular exosome] Show all	631 aa 70 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.