Expression of PABPC3 in cancer - Summary - The Human Protein Atlas

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PABPC3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PABPC3
Gene description	Poly(A) binding protein, cytoplasmic 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (U-266/84)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA045423
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable).
Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045423

GENE INFORMATION
Gene name	PABPC3 (HGNC Symbol)
Synonyms	PABP3, PABPL3, tPABP
Description	Poly(A) binding protein, cytoplasmic 3 (HGNC Symbol)
Entrez gene summary	Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]
Chromosome	13
Cytoband	q12.13
Chromosome location (bp)	25095868 - 25099254
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151846 (version 83.38)
Entrez gene	5042
UniProt	Q9H361 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H361
Antibodypedia	PABPC3 antibodies

PROTEIN BROWSER

PABPC3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PABPC3-001 ENSP00000281589 ENST00000281589	Q9H361 [Direct mapping] Polyadenylate-binding protein 3 Q5VX58 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] GO:0008143 [poly(A) binding] GO:0016071 [mRNA metabolic process] GO:0070062 [extracellular exosome] Show all	631 aa 70 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.