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DST

GENERAL INFORMATION

Gene name

 DST

Gene description

 Dystonin

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 19
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA030200
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DST (HGNC Symbol)

Synonyms

 BP240, BPA, BPAG1, CATX-15, FLJ13425, FLJ21489, FLJ30627, FLJ32235, KIAA0728, MACF2

Description

 Dystonin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]

Chromosome

 6

Cytoband

 p12.1

Chromosome location (bp)

 56457987 - 56954628

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151914 (version 83.38)

Entrez gene

 667

UniProt

 Q03001 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03001

Antibodypedia

 DST antibodies

PROTEIN BROWSER
«
DST-001
DST-004
DST-005
DST-009
DST-010
DST-011
DST-012
DST-015
DST-017
DST-018
DST-022
DST-024
DST-026
DST-028
DST-031
DST-033
DST-201
DST-202
DST-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DST-001
ENSP00000359824
ENST00000370788
E7ERU0 [Direct mapping]
Dystonin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
Show all
 5375 aa
615.7 kDa 		No 0
DST-004
ENSP00000354508
ENST00000361203
F8W9J4 [Direct mapping]
Dystonin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
GO:0015630 [microtubule cytoskeleton]
Show all
 7461 aa
848 kDa 		No 0
DST-005
ENSP00000244364
ENST00000244364
Q03001 [Direct mapping]
Dystonin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005882 [intermediate filament]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0009611 [response to wounding]
GO:0009925 [basal plasma membrane]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030011 [maintenance of cell polarity]
GO:0030018 [Z disc]
GO:0030056 [hemidesmosome]
GO:0030198 [extracellular matrix organization]
GO:0030424 [axon]
GO:0031252 [cell leading edge]
GO:0031581 [hemidesmosome assembly]
GO:0031673 [H zone]
GO:0035371 [microtubule plus-end]
GO:0042803 [protein homodimerization activity]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048870 [cell motility]
GO:0051010 [microtubule plus-end binding]
GO:0070062 [extracellular exosome]
Show all
 5171 aa
591 kDa 		No 0
DST-009
ENSP00000393082
ENST00000449297
Q5T0V7 [Direct mapping]
Dystonin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0016021 [integral component of membrane]
Show all
 689 aa
79.2 kDa 		No 0
DST-010
ENSP00000359801
ENST00000370765
Q03001 [Direct mapping]
Dystonin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0009611 [response to wounding]
GO:0009925 [basal plasma membrane]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030011 [maintenance of cell polarity]
GO:0030018 [Z disc]
GO:0030056 [hemidesmosome]
GO:0030198 [extracellular matrix organization]
GO:0030424 [axon]
GO:0031252 [cell leading edge]
GO:0031581 [hemidesmosome assembly]
GO:0031673 [H zone]
GO:0035371 [microtubule plus-end]
GO:0042803 [protein homodimerization activity]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048870 [cell motility]
GO:0051010 [microtubule plus-end binding]
GO:0070062 [extracellular exosome]
Show all
 2649 aa
306.8 kDa 		No 0
DST-011
ENSP00000404924
ENST00000439203
Q03001 [Direct mapping]
Dystonin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0009611 [response to wounding]
GO:0009925 [basal plasma membrane]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030011 [maintenance of cell polarity]
GO:0030018 [Z disc]
GO:0030056 [hemidesmosome]
GO:0030198 [extracellular matrix organization]
GO:0030424 [axon]
GO:0031252 [cell leading edge]
GO:0031581 [hemidesmosome assembly]
GO:0031673 [H zone]
GO:0035371 [microtubule plus-end]
GO:0042803 [protein homodimerization activity]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048870 [cell motility]
GO:0051010 [microtubule plus-end binding]
GO:0070062 [extracellular exosome]
Show all
 3060 aa
345 kDa 		No 0
DST-012
ENSP00000431030
ENST00000520645
E7ETB9 [Direct mapping]
Dystonin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
Show all
 1479 aa
171.5 kDa 		No 0
DST-015
ENSP00000431003
ENST00000518935
Q6P0N6 [Direct mapping]
DST protein; Dystonin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
Show all
 1143 aa
132.3 kDa 		No 0
DST-017
ENSP00000489032
ENST00000340834
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1674 aa
190.3 kDa 		No 0
DST-018
ENSP00000431020
ENST00000523292
H0YC65 [Direct mapping]
Dystonin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0007050 [cell cycle arrest]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 259 aa
27.8 kDa 		No 0
DST-022
ENSP00000429221
ENST00000523817
E7ERX3 [Direct mapping]
Dystonin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
Show all
 154 aa
18.2 kDa 		No 0
DST-024
ENSP00000429075
ENST00000522538
E7ESK0 [Direct mapping]
Dystonin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
Show all
 133 aa
15.6 kDa 		No 0
DST-026
ENSP00000428068
ENST00000522360
H0YAT7 [Direct mapping]
Dystonin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
Show all
 177 aa
20.6 kDa 		No 0
DST-028
ENSP00000489111
ENST00000524186
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 7 aa
0.8 kDa 		No 0
DST-031
ENSP00000430472
ENST00000523943
H0YBX0 [Direct mapping]
Dystonin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
Show all
 123 aa
14.3 kDa 		No 0
DST-033
ENSP00000488192
ENST00000633795
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 304 aa
33.9 kDa 		No 0
DST-201
ENSP00000307959
ENST00000312431
F6QMI7 [Direct mapping]
Dystonin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
GO:0007409 [axonogenesis]
GO:0008090 [retrograde axon cargo transport]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0030056 [hemidesmosome]
GO:0097481 [neuronal postsynaptic density]
Show all
 5537 aa
633.7 kDa 		No 0
DST-202
ENSP00000359790
ENST00000370754
E9PEB9 [Direct mapping]
Dystonin
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
GO:0015630 [microtubule cytoskeleton]
Show all
 5675 aa
649.5 kDa 		Yes 0
DST-203
ENSP00000400883
ENST00000421834
E9PHM6 [Direct mapping]
Dystonin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
Show all
 5497 aa
629.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.