Expression of KCNE4 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

KCNE4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCNE4
Gene description	Potassium channel, voltage gated subfamily E regulatory beta subunit 4
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (AN3-CA)
HPA (normal tissue):	Tissue enhanced (smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membrane expression in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA011420
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011420

GENE INFORMATION
Gene name	KCNE4 (HGNC Symbol)
Synonyms	MiRP3
Description	Potassium channel, voltage gated subfamily E regulatory beta subunit 4 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q36.1
Chromosome location (bp)	223051814 - 223198399
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152049 (version 83.38)
Entrez gene	23704
UniProt	Q8WWG9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWG9
Antibodypedia	KCNE4 antibodies

PROTEIN BROWSER

KCNE4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNE4-001 ENSP00000281830 ENST00000281830	Q8WWG9 [Direct mapping] Potassium voltage-gated channel subfamily E member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	221 aa 23.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.