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GEMIN6

GENERAL INFORMATION

Gene name

 GEMIN6

Gene description

 Gem (nuclear organelle) associated protein 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035726
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035726

GENE INFORMATION

Gene name

 GEMIN6 (HGNC Symbol)

Synonyms

 FLJ23459

Description

 Gem (nuclear organelle) associated protein 6 (HGNC Symbol)

Entrez gene summary

 GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]

Chromosome

 2

Cytoband

 p22.1

Chromosome location (bp)

 38751534 - 38785000

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152147 (version 83.38)

Entrez gene

 79833

UniProt

 Q8WXD5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXD5

Antibodypedia

 GEMIN6 antibodies

PROTEIN BROWSER
GEMIN6-001
GEMIN6-002
GEMIN6-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GEMIN6-001
ENSP00000281950
ENST00000281950
Q8WXD5 [Direct mapping]
Gem-associated protein 6
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000245 [spliceosomal complex assembly]
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0016604 [nuclear body]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0097504 [Gemini of coiled bodies]
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 167 aa
18.8 kDa 		No 0
GEMIN6-002
ENSP00000386613
ENST00000409566
B8ZZ85 [Direct mapping]
Gem (Nuclear organelle) associated protein 6, isoform CRA_b; Gem-associated protein 6
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000245 [spliceosomal complex assembly]
GO:0005634 [nucleus]
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 111 aa
12.4 kDa 		No 0
GEMIN6-003
ENSP00000387191
ENST00000409011
B9A037 [Direct mapping]
Gem-associated protein 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000245 [spliceosomal complex assembly]
GO:0005634 [nucleus]
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 69 aa
7.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.