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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PTH
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  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PTH

Gene description

Parathyroid hormone

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly specific expression in parathyroid gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 4 antibodies.
HPA048540 , CAB000072 , CAB023409 , CAB026363
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA048540
CAB000072
CAB023409
CAB026363

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Fraction of tumor cells in rare cases of duct carcinomas of breast showed moderate membranous staining. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells in general along with stromal cells were negative.

GENE INFORMATION

Gene name

PTH (HGNC Symbol)

Synonyms

PTH1

Description

Parathyroid hormone (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Chromosome

11

Cytoband

p15.3

Chromosome location (bp)

13492055 - 13496181

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000152266 (version 83.38)

Entrez gene

5741

UniProt

P01270 (UniProt - Evidence at protein level)

neXtProt

NX_P01270

Antibodypedia

PTH antibodies

PROTEIN BROWSER

PTH-001
PTH-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTH-001
ENSP00000282091
ENST00000282091
P01270 [Direct mapping]
Parathyroid hormone
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007266 [Rho protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0010288 [response to lead ion]
GO:0010468 [regulation of gene expression]
GO:0030501 [positive regulation of bone mineralization]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031667 [response to nutrient levels]
GO:0031856 [parathyroid hormone receptor binding]
GO:0031857 [type 1 parathyroid hormone receptor binding]
GO:0033280 [response to vitamin D]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0042493 [response to drug]
GO:0045453 [bone resorption]
GO:0045471 [response to ethanol]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045778 [positive regulation of ossification]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046058 [cAMP metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046686 [response to cadmium ion]
GO:0051428 [peptide hormone receptor binding]
GO:0071107 [response to parathyroid hormone]
GO:0071774 [response to fibroblast growth factor]
Show all
115 aa
12.9 kDa
Yes 0
PTH-002
ENSP00000433208
ENST00000529816
P01270 [Direct mapping]
Parathyroid hormone
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0010468 [regulation of gene expression]
GO:0030501 [positive regulation of bone mineralization]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031856 [parathyroid hormone receptor binding]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0045453 [bone resorption]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046058 [cAMP metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0051428 [peptide hormone receptor binding]
Show all
115 aa
12.9 kDa
Yes 0

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