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PTH
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PTH

Gene description

Parathyroid hormone

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (parathyroid gland)
GTEx:Tissue enriched (thyroid gland)
FANTOM5:Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression

Highly specific expression in parathyroid gland.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 4 antibodies.
HPA048540 , CAB000072 , CAB023409 , CAB026363
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Parathyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)

GENE INFORMATION

Gene name

PTH (HGNC Symbol)

Synonyms

PTH1

Description

Parathyroid hormone (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Chromosome

11

Cytoband

p15.3

Chromosome location (bp)

13492055 - 13496181

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000152266 (version 83.38)

Entrez gene

5741

UniProt

P01270 (UniProt - Evidence at protein level)

neXtProt

NX_P01270

Antibodypedia

PTH antibodies

PROTEIN BROWSER

PTH-001
PTH-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTH-001
ENSP00000282091
ENST00000282091
P01270 [Direct mapping]
Parathyroid hormone
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007266 [Rho protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0010288 [response to lead ion]
GO:0010468 [regulation of gene expression]
GO:0030501 [positive regulation of bone mineralization]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031667 [response to nutrient levels]
GO:0031856 [parathyroid hormone receptor binding]
GO:0031857 [type 1 parathyroid hormone receptor binding]
GO:0033280 [response to vitamin D]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0042493 [response to drug]
GO:0045453 [bone resorption]
GO:0045471 [response to ethanol]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045778 [positive regulation of ossification]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046058 [cAMP metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046686 [response to cadmium ion]
GO:0051428 [peptide hormone receptor binding]
GO:0071107 [response to parathyroid hormone]
GO:0071774 [response to fibroblast growth factor]
Show all
115 aa
12.9 kDa
Yes 0
PTH-002
ENSP00000433208
ENST00000529816
P01270 [Direct mapping]
Parathyroid hormone
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0010468 [regulation of gene expression]
GO:0030501 [positive regulation of bone mineralization]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031856 [parathyroid hormone receptor binding]
GO:0034645 [cellular macromolecule biosynthetic process]
GO:0045453 [bone resorption]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046058 [cAMP metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0051428 [peptide hormone receptor binding]
Show all
115 aa
12.9 kDa
Yes 0

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