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TCF7L1

GENERAL INFORMATION

Gene name

 TCF7L1

Gene description

 Transcription factor 7-like 1 (T-cell specific, HMG-box)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (NTERA-2, RH-30, T-47d)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable), renal cancer (unfavourable), stomach cancer (unfavourable) and urothelial cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
Renal cancer p<0.001
Stomach cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TCF7L1 (HGNC Symbol)

Synonyms

 TCF3

Description

 Transcription factor 7-like 1 (T-cell specific, HMG-box) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 85133410 - 85310388

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152284 (version 83.38)

Entrez gene

 83439

UniProt

 Q9HCS4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9HCS4

Antibodypedia

 TCF7L1 antibodies

PROTEIN BROWSER
TCF7L1-001
TCF7L1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCF7L1-001
ENSP00000282111
ENST00000282111
Q9HCS4 [Direct mapping]
Transcription factor 7-like 1
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0008595 [anterior/posterior axis specification, embryo]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0035019 [somatic stem cell population maintenance]
GO:0043565 [sequence-specific DNA binding]
GO:0043588 [skin development]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046022 [positive regulation of transcription from RNA polymerase II promoter during mitosis]
GO:0048319 [axial mesoderm morphogenesis]
GO:0048699 [generation of neurons]
GO:0048863 [stem cell differentiation]
GO:0060070 [canonical Wnt signaling pathway]
GO:2000036 [regulation of stem cell population maintenance]
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 588 aa
62.6 kDa 		No 0
TCF7L1-004
ENSP00000388984
ENST00000442813
C9JPE3 [Direct mapping]
Transcription factor 7-like 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 29 aa
3.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.