Tissue expression of TCF7L1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TCF7L1
Gene description	Transcription factor 7-like 1 (T-cell specific, HMG-box)
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TCF7L1 (HGNC Symbol)
Synonyms	TCF3
Description	Transcription factor 7-like 1 (T-cell specific, HMG-box) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]
Chromosome	2
Cytoband	p11.2
Chromosome location (bp)	85133410 - 85310388
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152284 (version 83.38)
Entrez gene	83439
UniProt	Q9HCS4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9HCS4
Antibodypedia	TCF7L1 antibodies

PROTEIN BROWSER

TCF7L1-001	TCF7L1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TCF7L1-001 ENSP00000282111 ENST00000282111	Q9HCS4 [Direct mapping] Transcription factor 7-like 1 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0008595 [anterior/posterior axis specification, embryo] GO:0030111 [regulation of Wnt signaling pathway] GO:0035019 [somatic stem cell population maintenance] GO:0043565 [sequence-specific DNA binding] GO:0043588 [skin development] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046022 [positive regulation of transcription from RNA polymerase II promoter during mitosis] GO:0048319 [axial mesoderm morphogenesis] GO:0048699 [generation of neurons] GO:0048863 [stem cell differentiation] GO:0060070 [canonical Wnt signaling pathway] GO:2000036 [regulation of stem cell population maintenance] Show all	588 aa 62.6 kDa	No	0
TCF7L1-004 ENSP00000388984 ENST00000442813	C9JPE3 [Direct mapping] Transcription factor 7-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005667 [transcription factor complex] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0048699 [generation of neurons] GO:0060070 [canonical Wnt signaling pathway] Show all	29 aa 3.2 kDa	No	0