Fields »
ABOUT
HELP
BLOG
ATG10

GENERAL INFORMATION

Gene name

 ATG10

Gene description

 Autophagy related 10

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044163
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044163

GENE INFORMATION

Gene name

 ATG10 (HGNC Symbol)

Synonyms

 APG10L, DKFZP586I0418, FLJ13954

Description

 Autophagy related 10 (HGNC Symbol)

Entrez gene summary

 Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]

Chromosome

 5

Cytoband

Chromosome location (bp)

 81972025 - 82276857

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152348 (version 83.38)

Entrez gene

 83734

UniProt

 Q9H0Y0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0Y0

Antibodypedia

 ATG10 antibodies

PROTEIN BROWSER
ATG10-001
ATG10-002
ATG10-003
ATG10-006
ATG10-008
ATG10-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG10-001
ENSP00000282185
ENST00000282185
Q9H0Y0 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG10
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0016874 [ligase activity]
GO:0019777 [Atg12 transferase activity]
GO:0031401 [positive regulation of protein modification process]
GO:0032446 [protein modification by small protein conjugation]
GO:0034263 [autophagy in response to ER overload]
Show all
 220 aa
25.3 kDa 		No 0
ATG10-002
ENSP00000425182
ENST00000513443
Q9H0Y0 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG10
A0A024RAK8 [Target identity:100%; Query identity:100%]
ATG10 autophagy related 10 homolog (S. cerevisiae), isoform CRA_a
Show all
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0016874 [ligase activity]
GO:0019777 [Atg12 transferase activity]
GO:0031401 [positive regulation of protein modification process]
GO:0032446 [protein modification by small protein conjugation]
GO:0034263 [autophagy in response to ER overload]
Show all
 125 aa
14.2 kDa 		No 0
ATG10-003
ENSP00000347309
ENST00000355178
Q9H0Y0 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG10
A0A024RAK8 [Target identity:100%; Query identity:100%]
ATG10 autophagy related 10 homolog (S. cerevisiae), isoform CRA_a
Show all
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0016874 [ligase activity]
GO:0019777 [Atg12 transferase activity]
GO:0031401 [positive regulation of protein modification process]
GO:0032446 [protein modification by small protein conjugation]
GO:0034263 [autophagy in response to ER overload]
Show all
 125 aa
14.2 kDa 		No 0
ATG10-006
ENSP00000422340
ENST00000510085
D6RC89 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG10
Show all
Predicted intracellular proteins
Show all
GO:0006497 [protein lipidation]
GO:0019777 [Atg12 transferase activity]
Show all
 36 aa
4.4 kDa 		No 0
ATG10-008
ENSP00000425225
ENST00000513634
D6RDX3 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG10
Show all
Predicted intracellular proteins
Show all
GO:0006497 [protein lipidation]
GO:0019777 [Atg12 transferase activity]
Show all
 184 aa
21.4 kDa 		No 0
ATG10-012
ENSP00000404938
ENST00000458350
Q9H0Y0 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG10
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0016874 [ligase activity]
GO:0019777 [Atg12 transferase activity]
GO:0031401 [positive regulation of protein modification process]
GO:0032446 [protein modification by small protein conjugation]
GO:0034263 [autophagy in response to ER overload]
Show all
 220 aa
25.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.