Cell atlas - RASGRP3 - The Human Protein Atlas

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RASGRP3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleoplasm

Human cell
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RASGRP3
Gene description	RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Protein class	Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.
RNA cell category	Group enriched (U-266/70, HEL, Daudi, U-266/84, U-698)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058937
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-266/70, HEL, Daudi, U-266/84, U-698) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.

Main location

Nucleoplasm (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058937	CACO-2	Nucleoplasm
	HPA058937	CACO-2	Golgi apparatus
	HPA058937	RH-30	Nucleoplasm
	HPA058937	U-2 OS	Nucleoplasm
	HPA058937	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	RASGRP3 (HGNC Symbol)
Synonyms	GRP3, KIAA0846
Description	RAS guanyl releasing protein 3 (calcium and DAG-regulated) (HGNC Symbol)
Entrez gene summary	Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	p22.3
Chromosome location (bp)	33436324 - 33564750
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152689 (version 83.38)
Entrez gene	25780
UniProt	Q8IV61 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IV61
Antibodypedia	RASGRP3 antibodies

PROTEIN BROWSER

RASGRP3-001	RASGRP3-004	RASGRP3-006	RASGRP3-007	RASGRP3-008	RASGRP3-012	RASGRP3-013	RASGRP3-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RASGRP3-001 ENSP00000385886 ENST00000402538	Q8IV61 [Direct mapping] Ras guanyl-releasing protein 3 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004871 [signal transducer activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019992 [diacylglycerol binding] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	690 aa 78.3 kDa	No	0
RASGRP3-004 ENSP00000383917 ENST00000407811	Q8IV61 [Direct mapping] Ras guanyl-releasing protein 3 A0A0A6YYA9 [Direct mapping] Ras guanyl-releasing protein 3 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004871 [signal transducer activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019992 [diacylglycerol binding] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	689 aa 78.2 kDa	No	0
RASGRP3-006 ENSP00000384192 ENST00000403687	Q8IV61 [Direct mapping] Ras guanyl-releasing protein 3 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004871 [signal transducer activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0017016 [Ras GTPase binding] GO:0019900 [kinase binding] GO:0019992 [diacylglycerol binding] GO:0032045 [guanyl-nucleotide exchange factor complex] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043087 [regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] Show all	690 aa 78.3 kDa	No	0
RASGRP3-007 ENSP00000393866 ENST00000437184	C9K0P4 [Direct mapping] Ras guanyl-releasing protein 3 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007265 [Ras protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	172 aa 20.2 kDa	No	0
RASGRP3-008 ENSP00000401974 ENST00000425210	C9JSS2 [Direct mapping] Ras guanyl-releasing protein 3 Show all	Predicted intracellular proteins RAS pathway related proteins Show all		34 aa 3.6 kDa	No	0
RASGRP3-012 ENSP00000405648 ENST00000442390	C9J9C9 [Direct mapping] Ras guanyl-releasing protein 3 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007265 [Ras protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	77 aa 8.8 kDa	No	0
RASGRP3-013 ENSP00000388139 ENST00000423159	C9JWP0 [Direct mapping] Ras guanyl-releasing protein 3 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007265 [Ras protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	113 aa 13.2 kDa	No	0
RASGRP3-014 ENSP00000400602 ENST00000444784	C9IYA5 [Direct mapping] Ras guanyl-releasing protein 3 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007265 [Ras protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	112 aa 13.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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