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RASGRP3

GENERAL INFORMATION

Gene name

 RASGRP3

Gene description

 RAS guanyl releasing protein 3 (calcium and DAG-regulated)

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (Daudi, HEL, U-266/70, U-266/84, U-698)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RASGRP3 (HGNC Symbol)

Synonyms

 GRP3, KIAA0846

Description

 RAS guanyl releasing protein 3 (calcium and DAG-regulated) (HGNC Symbol)

Entrez gene summary

 Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 p22.3

Chromosome location (bp)

 33436324 - 33564750

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152689 (version 83.38)

Entrez gene

 25780

UniProt

 Q8IV61 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IV61

Antibodypedia

 RASGRP3 antibodies

PROTEIN BROWSER
RASGRP3-001
RASGRP3-004
RASGRP3-006
RASGRP3-007
RASGRP3-008
RASGRP3-012
RASGRP3-013
RASGRP3-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASGRP3-001
ENSP00000385886
ENST00000402538
Q8IV61 [Direct mapping]
Ras guanyl-releasing protein 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004871 [signal transducer activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019992 [diacylglycerol binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 690 aa
78.3 kDa 		No 0
RASGRP3-004
ENSP00000383917
ENST00000407811
Q8IV61 [Direct mapping]
Ras guanyl-releasing protein 3
A0A0A6YYA9 [Direct mapping]
Ras guanyl-releasing protein 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004871 [signal transducer activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019992 [diacylglycerol binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 689 aa
78.2 kDa 		No 0
RASGRP3-006
ENSP00000384192
ENST00000403687
Q8IV61 [Direct mapping]
Ras guanyl-releasing protein 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004871 [signal transducer activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0017016 [Ras GTPase binding]
GO:0019900 [kinase binding]
GO:0019992 [diacylglycerol binding]
GO:0032045 [guanyl-nucleotide exchange factor complex]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 690 aa
78.3 kDa 		No 0
RASGRP3-007
ENSP00000393866
ENST00000437184
C9K0P4 [Direct mapping]
Ras guanyl-releasing protein 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005622 [intracellular]
GO:0007265 [Ras protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 172 aa
20.2 kDa 		No 0
RASGRP3-008
ENSP00000401974
ENST00000425210
C9JSS2 [Direct mapping]
Ras guanyl-releasing protein 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 34 aa
3.6 kDa 		No 0
RASGRP3-012
ENSP00000405648
ENST00000442390
C9J9C9 [Direct mapping]
Ras guanyl-releasing protein 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005622 [intracellular]
GO:0007265 [Ras protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 77 aa
8.8 kDa 		No 0
RASGRP3-013
ENSP00000388139
ENST00000423159
C9JWP0 [Direct mapping]
Ras guanyl-releasing protein 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005622 [intracellular]
GO:0007265 [Ras protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 113 aa
13.2 kDa 		No 0
RASGRP3-014
ENSP00000400602
ENST00000444784
C9IYA5 [Direct mapping]
Ras guanyl-releasing protein 3
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005622 [intracellular]
GO:0007265 [Ras protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 112 aa
13.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.