Expression of ADGRA3 in cancer - Summary - The Human Protein Atlas

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ADGRA3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADGRA3
Gene description	Adhesion G protein-coupled receptor A3
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA008904
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008904

GENE INFORMATION
Gene name	ADGRA3 (HGNC Symbol)
Synonyms	FLJ38547, GPR125, PGR21
Description	Adhesion G protein-coupled receptor A3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
Chromosome	4
Cytoband	p15.2
Chromosome location (bp)	22345071 - 22516054
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152990 (version 83.38)
Entrez gene	166647
UniProt	Q8IWK6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWK6
Antibodypedia	ADGRA3 antibodies

PROTEIN BROWSER

ADGRA3-001	ADGRA3-010	ADGRA3-014	ADGRA3-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRA3-001 ENSP00000334952 ENST00000334304	Q8IWK6 [Direct mapping] Adhesion G protein-coupled receptor A3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1321 aa 146.1 kDa	Yes	7
ADGRA3-010 ENSP00000422606 ENST00000508133	Q8IWK6 [Direct mapping] Adhesion G protein-coupled receptor A3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	381 aa 43 kDa	No	0
ADGRA3-014 ENSP00000421006 ENST00000502482	Q8IWK6 [Direct mapping] Adhesion G protein-coupled receptor A3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	616 aa 68.2 kDa	Yes	0
ADGRA3-021 ENSP00000425223 ENST00000514129	D6RDX4 [Direct mapping] Adhesion G protein-coupled receptor A3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	97 aa 10.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.