Expression of CPB1 in cancer - Summary - The Human Protein Atlas

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CPB1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CPB1
Gene description	Carboxypeptidase B1 (tissue)
Protein class	Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, pancreatic cancer)
HPA (cell line):	Cell line enhanced (HDLM-2, U-2 OS)
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in exocrine glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA038069 , HPA046340 , CAB026158
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA038069	HPA046340	CAB026158

GENE INFORMATION
Gene name	CPB1
Synonyms
Description	Carboxypeptidase B1 (tissue) (HGNC Symbol)
Entrez gene summary	Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q24
Chromosome location (bp)	148791102 - 148860187
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153002 (version 83.38)
Entrez gene	1360
UniProt	P15086 (UniProt - Evidence at protein level)
neXtProt	NX_P15086
Antibodypedia	CPB1 antibodies

PROTEIN BROWSER

CPB1-001	CPB1-003	CPB1-004	CPB1-014	CPB1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPB1-001 ENSP00000417222 ENST00000491148	P15086 [Direct mapping] Carboxypeptidase B Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	417 aa 47.4 kDa	Yes	0
CPB1-003 ENSP00000417117 ENST00000462345	C9J5C4 [Direct mapping] Carboxypeptidase B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0006508 [proteolysis] Show all	99 aa 11.2 kDa	Yes	0
CPB1-004 ENSP00000419114 ENST00000494888	C9JXS3 [Direct mapping] Carboxypeptidase B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0006508 [proteolysis] Show all	59 aa 6.6 kDa	Yes	0
CPB1-014 ENSP00000419427 ENST00000468341	C9JUX7 [Direct mapping] Carboxypeptidase B Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	203 aa 23.6 kDa	Yes	0
CPB1-201 ENSP00000282957 ENST00000282957	P15086 [Direct mapping] Carboxypeptidase B Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	417 aa 47.4 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.