Cell atlas - ANAPC1 - The Human Protein Atlas

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ANAPC1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	ANAPC1
Gene description	Anaphase promoting complex subunit 1
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042998
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042998	A-431	Vesicles
	HPA042998	U-2 OS	Vesicles

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000014355 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA042998	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	ANAPC1 (HGNC Symbol)
Synonyms	APC1, MCPR, TSG24
Description	Anaphase promoting complex subunit 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]
Chromosome	2
Cytoband	q13
Chromosome location (bp)	111766271 - 111884690
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153107 (version 83.38)
Entrez gene	64682
UniProt	Q9H1A4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H1A4
Antibodypedia	ANAPC1 antibodies

PROTEIN BROWSER

ANAPC1-001	ANAPC1-005	ANAPC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANAPC1-001 ENSP00000339109 ENST00000341068	Q9H1A4 [Direct mapping] Anaphase-promoting complex subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007094 [mitotic spindle assembly checkpoint] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070979 [protein K11-linked ubiquitination] Show all	1944 aa 216.5 kDa	No	1
ANAPC1-005 ENSP00000396695 ENST00000427997	H0Y564 [Direct mapping] Anaphase-promoting complex subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] Show all	1452 aa 161.5 kDa	No	1
ANAPC1-201 ENSP00000486322 ENST00000628342	F8WAS1 [Direct mapping] Anaphase-promoting complex subunit 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] Show all	149 aa 16.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.