Expression of ANAPC1 in cancer - Summary

GENERAL INFORMATION
Gene name	ANAPC1
Gene description	Anaphase promoting complex subunit 1
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissue types, most abundant in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA036329 , HPA036330 , HPA042998
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA036329	HPA036330	HPA042998

GENE INFORMATION
Gene name	ANAPC1 (HGNC Symbol)
Synonyms	APC1, MCPR, TSG24
Description	Anaphase promoting complex subunit 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]
Chromosome	2
Cytoband	q13
Chromosome location (bp)	111766271 - 111884690
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153107 (version 83.38)
Entrez gene	64682
UniProt	Q9H1A4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H1A4
Antibodypedia	ANAPC1 antibodies

PROTEIN BROWSER

ANAPC1-001	ANAPC1-005	ANAPC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANAPC1-001 ENSP00000339109 ENST00000341068	Q9H1A4 [Direct mapping] Anaphase-promoting complex subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007094 [mitotic spindle assembly checkpoint] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070979 [protein K11-linked ubiquitination] Show all	1944 aa 216.5 kDa	No	1
ANAPC1-005 ENSP00000396695 ENST00000427997	H0Y564 [Direct mapping] Anaphase-promoting complex subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] Show all	1452 aa 161.5 kDa	No	1
ANAPC1-201 ENSP00000486322 ENST00000628342	F8WAS1 [Direct mapping] Anaphase-promoting complex subunit 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] Show all	149 aa 16.9 kDa	No	0