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NR4A2

GENERAL INFORMATION

Gene name

 NR4A2

Gene description

 Nuclear receptor subfamily 4, group A, member 2

Protein class

 Cancer-related genes
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HeLa, HMC-1, U-266/70)
HPA (normal tissue):Tissue enhanced (adrenal gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA000543 , CAB010481
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000543
CAB010481

GENE INFORMATION

Gene name

 NR4A2 (HGNC Symbol)

Synonyms

 HZF-3, NOT, NURR1, RNR1, TINUR

Description

 Nuclear receptor subfamily 4, group A, member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q24.1

Chromosome location (bp)

 156324432 - 156342348

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153234 (version 83.38)

Entrez gene

 4929

UniProt

 P43354 (UniProt - Evidence at protein level)

neXtProt

 NX_P43354

Antibodypedia

 NR4A2 antibodies

PROTEIN BROWSER
NR4A2-001
NR4A2-003
NR4A2-004
NR4A2-005
NR4A2-007
NR4A2-008
NR4A2-009
NR4A2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR4A2-001
ENSP00000344479
ENST00000339562
P43354 [Direct mapping]
Nuclear receptor subfamily 4 group A member 2
F1D8N6 [Target identity:100%; Query identity:100%]
Nuclear receptor related 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001666 [response to hypoxia]
GO:0001764 [neuron migration]
GO:0001975 [response to amphetamine]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0008344 [adult locomotory behavior]
GO:0009791 [post-embryonic development]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0021952 [central nervous system projection neuron axonogenesis]
GO:0021953 [central nervous system neuron differentiation]
GO:0021986 [habenula development]
GO:0030182 [neuron differentiation]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031668 [cellular response to extracellular stimulus]
GO:0034599 [cellular response to oxidative stress]
GO:0035259 [glucocorticoid receptor binding]
GO:0042053 [regulation of dopamine metabolic process]
GO:0042416 [dopamine biosynthetic process]
GO:0042417 [dopamine metabolic process]
GO:0042551 [neuron maturation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043576 [regulation of respiratory gaseous exchange]
GO:0045444 [fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0051866 [general adaptation syndrome]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
GO:0071542 [dopaminergic neuron differentiation]
Show all
 598 aa
66.6 kDa 		No 0
NR4A2-003
ENSP00000389986
ENST00000426264
P43354 [Direct mapping]
Nuclear receptor subfamily 4 group A member 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031668 [cellular response to extracellular stimulus]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045444 [fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
GO:0071542 [dopaminergic neuron differentiation]
Show all
 535 aa
59.8 kDa 		No 0
NR4A2-004
ENSP00000388120
ENST00000421709
C9JWQ1 [Direct mapping]
Nuclear receptor subfamily 4 group A member 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003677 [DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
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 107 aa
12.2 kDa 		No 0
NR4A2-005
ENSP00000406808
ENST00000424077
C9IYM5 [Direct mapping]
Nuclear receptor subfamily 4 group A member 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003677 [DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
Show all
 258 aa
28.3 kDa 		No 0
NR4A2-007
ENSP00000385379
ENST00000406048
H7BZ00 [Direct mapping]
Nuclear receptor subfamily 4 group A member 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 150 aa
16.7 kDa 		No 0
NR4A2-008
ENSP00000410952
ENST00000429376
C9J8W4 [Direct mapping]
Nuclear receptor subfamily 4 group A member 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 490 aa
54.6 kDa 		No 0
NR4A2-009
ENSP00000386993
ENST00000409108
F8W6I3 [Direct mapping]
Nuclear receptor subfamily 4 group A member 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 553 aa
61.4 kDa 		No 0
NR4A2-010
ENSP00000386747
ENST00000409572
P43354 [Direct mapping]
Nuclear receptor subfamily 4 group A member 2
F1D8N6 [Target identity:100%; Query identity:100%]
Nuclear receptor related 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031668 [cellular response to extracellular stimulus]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045444 [fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
GO:0071542 [dopaminergic neuron differentiation]
Show all
 598 aa
66.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.