Cell atlas - ASAP1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ASAP1
Gene description	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, cytosol & centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Centrosome (approved), Cytosol (approved)
Mouse	Localized to the Plasma membrane, Microtubule organizing center, Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048565
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, cytosol & centrosome.

Main location

Plasma membrane (approved), Centrosome (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA048565	A-431	Centrosome
HPA048565	U-2 OS	Plasma membrane
HPA048565	U-2 OS	Cytosol
HPA048565	U-251 MG	Centrosome

MOUSE CELLS

Main location

Plasma membrane, Microtubule organizing center, Cytosol

Mouse gene

ENSMUSG00000022377 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA048565	NIH 3T3	Plasma membrane
		Microtubule organizing center
		Cytosol

GENE INFORMATION
Gene name	ASAP1 (HGNC Symbol)
Synonyms	CENTB4, DDEF1, KIAA1249, PAP, ZG14P
Description	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	8
Cytoband
Chromosome location (bp)	130052104 - 130443660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153317 (version 83.38)
Entrez gene	50807
UniProt	Q9ULH1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULH1
Antibodypedia	ASAP1 antibodies

PROTEIN BROWSER

ASAP1-001	ASAP1-004	ASAP1-007	ASAP1-010	ASAP1-015	ASAP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASAP1-001 ENSP00000429900 ENST00000518721	Q9ULH1 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0016020 [membrane] GO:0043197 [dendritic spine] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0060271 [cilium morphogenesis] GO:0061000 [negative regulation of dendritic spine development] Show all	1129 aa 125.5 kDa	No	0
ASAP1-004 ENSP00000429391 ENST00000524124	H0YBF7 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	950 aa 105.1 kDa	No	0
ASAP1-007 ENSP00000430917 ENST00000521426	E5RHD7 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.2 kDa	No	0
ASAP1-010 ENSP00000428936 ENST00000520342	E5RFD9 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 4 kDa	No	0
ASAP1-015 ENSP00000429829 ENST00000519483	H0YBM4 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	484 aa 52.9 kDa	No	0
ASAP1-201 ENSP00000350297 ENST00000357668	A0A0A0MRE5 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Development and differentiation enhancing factor 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	1122 aa 124.8 kDa	No	0