Expression of ASAP1 in cancer - Summary - The Human Protein Atlas

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ASAP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASAP1
Gene description	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA011136 , HPA048565 , CAB037292
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable), lung cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Lung cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011136	HPA048565	CAB037292

GENE INFORMATION
Gene name	ASAP1 (HGNC Symbol)
Synonyms	CENTB4, DDEF1, KIAA1249, PAP, ZG14P
Description	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	8
Cytoband
Chromosome location (bp)	130052104 - 130443660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153317 (version 83.38)
Entrez gene	50807
UniProt	Q9ULH1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULH1
Antibodypedia	ASAP1 antibodies

PROTEIN BROWSER

ASAP1-001	ASAP1-004	ASAP1-007	ASAP1-010	ASAP1-015	ASAP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASAP1-001 ENSP00000429900 ENST00000518721	Q9ULH1 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0016020 [membrane] GO:0043197 [dendritic spine] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0060271 [cilium morphogenesis] GO:0061000 [negative regulation of dendritic spine development] Show all	1129 aa 125.5 kDa	No	0
ASAP1-004 ENSP00000429391 ENST00000524124	H0YBF7 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	950 aa 105.1 kDa	No	0
ASAP1-007 ENSP00000430917 ENST00000521426	E5RHD7 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.2 kDa	No	0
ASAP1-010 ENSP00000428936 ENST00000520342	E5RFD9 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 4 kDa	No	0
ASAP1-015 ENSP00000429829 ENST00000519483	H0YBM4 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	484 aa 52.9 kDa	No	0
ASAP1-201 ENSP00000350297 ENST00000357668	A0A0A0MRE5 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Development and differentiation enhancing factor 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	1122 aa 124.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.