Expression of INO80C in cancer - Summary - The Human Protein Atlas

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INO80C

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	INO80C
Gene description	INO80 complex subunit C
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA049060
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and cervical cancer (favourable).
Endometrial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049060

GENE INFORMATION
Gene name	INO80C (HGNC Symbol)
Synonyms	C18orf37, FLJ38183, hIes6, IES6
Description	INO80 complex subunit C (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q12.2
Chromosome location (bp)	35452230 - 35497991
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153391 (version 83.38)
Entrez gene	125476
UniProt	Q6PI98 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PI98
Antibodypedia	INO80C antibodies

PROTEIN BROWSER

INO80C-001	INO80C-002	INO80C-003	INO80C-005	INO80C-008	INO80C-009	INO80C-010	INO80C-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INO80C-001 ENSP00000334473 ENST00000334598	Q6PI98 [Direct mapping] INO80 complex subunit C Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006310 [DNA recombination] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0031011 [Ino80 complex] GO:0071339 [MLL1 complex] Show all	192 aa 20.6 kDa	No	0
INO80C-002 ENSP00000391457 ENST00000441607	Q6PI98 [Direct mapping] INO80 complex subunit C Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006310 [DNA recombination] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0031011 [Ino80 complex] GO:0071339 [MLL1 complex] Show all	228 aa 24.5 kDa	No	0
INO80C-003 ENSP00000465273 ENST00000592173	Q6PI98 [Direct mapping] INO80 complex subunit C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006310 [DNA recombination] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0031011 [Ino80 complex] GO:0071339 [MLL1 complex] Show all	197 aa 21.1 kDa	No	1
INO80C-005 ENSP00000467013 ENST00000587450	K7ENM4 [Direct mapping] INO80 complex subunit C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0031011 [Ino80 complex] Show all	98 aa 10.1 kDa	No	0
INO80C-008 ENSP00000467708 ENST00000590757	K7EQ79 [Direct mapping] INO80 complex subunit C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0031011 [Ino80 complex] Show all	95 aa 10.1 kDa	No	0
INO80C-009 ENSP00000464948 ENST00000586489	K7EIY8 [Direct mapping] Chromosome 18 open reading frame 37, isoform CRA_a; INO80 complex subunit C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0031011 [Ino80 complex] Show all	137 aa 15.2 kDa	No	0
INO80C-010 ENSP00000465637 ENST00000589273	K7EKI6 [Direct mapping] INO80 complex subunit C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.2 kDa	No	0
INO80C-011 ENSP00000473165 ENST00000591139	M0R3E2 [Direct mapping] INO80 complex subunit C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0031011 [Ino80 complex] Show all	137 aa 14.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.