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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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LPCAT1
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

LPCAT1

Gene description

Lysophosphatidylcholine acyltransferase 1

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO, EFO-21)
HPA (normal tissue):Tissue enhanced (lung, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression of varying intensity.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA012501 , HPA022268
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable), pancreatic cancer (favourable), cervical cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Pancreatic cancer p<0.001
Cervical cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA012501
HPA022268

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells predominantly displayed weak to moderate cytoplasmic immunoreactivity. Most colorectal, lung and ovarian cancers were strongly positive.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells showed moderate to strong cytoplasmic immunoreactivity. Several hepatocellular carcinomas were negative.

GENE INFORMATION

Gene name

LPCAT1 (HGNC Symbol)

Synonyms

AGPAT10, AGPAT9, AYTL2, FLJ12443

Description

Lysophosphatidylcholine acyltransferase 1 (HGNC Symbol)

Entrez gene summary

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006 [PubMed 16704971]).[supplied by OMIM, May 2008]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

1456480 - 1523977

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000153395 (version 83.38)

Entrez gene

79888

UniProt

Q8NF37 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NF37

Antibodypedia

LPCAT1 antibodies

PROTEIN BROWSER

LPCAT1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LPCAT1-002
ENSP00000283415
ENST00000283415
Q8NF37 [Direct mapping]
Lysophosphatidylcholine acyltransferase 1
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid particle]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008654 [phospholipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0019432 [triglyceride biosynthetic process]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0043129 [surfactant homeostasis]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047159 [1-alkenylglycerophosphocholine O-acyltransferase activity]
GO:0047184 [1-acylglycerophosphocholine O-acyltransferase activity]
GO:0047191 [1-alkylglycerophosphocholine O-acyltransferase activity]
GO:0047192 [1-alkylglycerophosphocholine O-acetyltransferase activity]
GO:0060041 [retina development in camera-type eye]
GO:2001246 [negative regulation of phosphatidylcholine biosynthetic process]
Show all
534 aa
59.2 kDa
No 1

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