Cell atlas - ING1 - The Human Protein Atlas

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ING1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ING1
Gene description	Inhibitor of growth family, member 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA052591
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA052591	A-431	Nucleoplasm
	HPA052591	A-431	Cytosol
	HPA052591	U-2 OS	Nucleoplasm
	HPA052591	U-251 MG	Nucleoplasm
	HPA052591	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ING1 (HGNC Symbol)
Synonyms	p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
Description	Inhibitor of growth family, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q34
Chromosome location (bp)	110712736 - 110723339
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153487 (version 83.38)
Entrez gene	3621
UniProt	Q9UK53 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UK53
Antibodypedia	ING1 antibodies

PROTEIN BROWSER

ING1-001	ING1-002	ING1-003	ING1-004	ING1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ING1-001 ENSP00000328436 ENST00000333219	Q9UK53 [Direct mapping] Inhibitor of growth protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007049 [cell cycle] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] GO:0030308 [negative regulation of cell growth] GO:0035064 [methylated histone binding] Show all	279 aa 31.9 kDa	No	0
ING1-002 ENSP00000364930 ENST00000375775	Q9UK53 [Direct mapping] Inhibitor of growth protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007049 [cell cycle] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] GO:0030308 [negative regulation of cell growth] GO:0035064 [methylated histone binding] Show all	210 aa 23.7 kDa	No	0
ING1-003 ENSP00000345202 ENST00000338450	Q9UK53 [Direct mapping] Inhibitor of growth protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007049 [cell cycle] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] GO:0030308 [negative regulation of cell growth] GO:0035064 [methylated histone binding] Show all	235 aa 26.8 kDa	No	0
ING1-004 ENSP00000364929 ENST00000375774	A0A0C4DFW2 [Direct mapping] Inhibitor of growth protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006606 [protein import into nucleus] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	422 aa 46.8 kDa	No	0
ING1-005 ENSP00000480985 ENST00000464141	A0A087WXF7 [Direct mapping] Inhibitor of growth protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] Show all	111 aa 12.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.