Expression of ING1 in cancer - Summary - The Human Protein Atlas

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ING1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ING1
Gene description	Inhibitor of growth family, member 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. CAB016136 , CAB017773
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB016136	CAB017773

GENE INFORMATION
Gene name	ING1 (HGNC Symbol)
Synonyms	p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
Description	Inhibitor of growth family, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q34
Chromosome location (bp)	110712736 - 110723339
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153487 (version 83.38)
Entrez gene	3621
UniProt	Q9UK53 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UK53
Antibodypedia	ING1 antibodies

PROTEIN BROWSER

ING1-001	ING1-002	ING1-003	ING1-004	ING1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ING1-001 ENSP00000328436 ENST00000333219	Q9UK53 [Direct mapping] Inhibitor of growth protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007049 [cell cycle] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] GO:0030308 [negative regulation of cell growth] GO:0035064 [methylated histone binding] Show all	279 aa 31.9 kDa	No	0
ING1-002 ENSP00000364930 ENST00000375775	Q9UK53 [Direct mapping] Inhibitor of growth protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007049 [cell cycle] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] GO:0030308 [negative regulation of cell growth] GO:0035064 [methylated histone binding] Show all	210 aa 23.7 kDa	No	0
ING1-003 ENSP00000345202 ENST00000338450	Q9UK53 [Direct mapping] Inhibitor of growth protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007049 [cell cycle] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] GO:0030308 [negative regulation of cell growth] GO:0035064 [methylated histone binding] Show all	235 aa 26.8 kDa	No	0
ING1-004 ENSP00000364929 ENST00000375774	A0A0C4DFW2 [Direct mapping] Inhibitor of growth protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006606 [protein import into nucleus] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	422 aa 46.8 kDa	No	0
ING1-005 ENSP00000480985 ENST00000464141	A0A087WXF7 [Direct mapping] Inhibitor of growth protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0008285 [negative regulation of cell proliferation] GO:0010941 [regulation of cell death] GO:0016568 [chromatin modification] Show all	111 aa 12.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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