Cell atlas - JAZF1 - The Human Protein Atlas

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JAZF1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	JAZF1
Gene description	JAZF zinc finger 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli (fibrillar center).
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nucleoli fibrillar center (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA066967
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli (fibrillar center).

Main location

Nucleus (supported), Nucleoli fibrillar center (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066967	HEK 293	Nucleus
	HPA066967	HEK 293	Nucleoli fibrillar center
	HPA066967	U-2 OS	Nucleus
	HPA066967	U-2 OS	Nucleoli fibrillar center
	HPA066967	U-251 MG	Nucleus
			Nucleoli fibrillar center
			Cytosol

GENE INFORMATION
Gene name	JAZF1 (HGNC Symbol)
Synonyms	DKFZp761K2222, TIP27, ZNF802
Description	JAZF zinc finger 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband
Chromosome location (bp)	27830573 - 28180743
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153814 (version 83.38)
Entrez gene	221895
UniProt	Q86VZ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VZ6
Antibodypedia	JAZF1 antibodies

PROTEIN BROWSER

JAZF1-001	JAZF1-002	JAZF1-004	JAZF1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
JAZF1-001 ENSP00000283928 ENST00000283928	Q86VZ6 [Direct mapping] Juxtaposed with another zinc finger protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003676 [nucleic acid binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006629 [lipid metabolic process] GO:0017053 [transcriptional repressor complex] GO:0046872 [metal ion binding] Show all	243 aa 27.1 kDa	No	0
JAZF1-002 ENSP00000387976 ENST00000430432	C9JWY1 [Direct mapping] Juxtaposed with another zinc finger protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	173 aa 19.3 kDa	No	0
JAZF1-004 ENSP00000415096 ENST00000447620	C9JGY8 [Direct mapping] Juxtaposed with another zinc finger protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	181 aa 20.1 kDa	No	0
JAZF1-008 ENSP00000388302 ENST00000427814	H0Y403 [Direct mapping] Juxtaposed with another zinc finger protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	230 aa 25.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.