Expression of JAZF1 in cancer - Summary - The Human Protein Atlas

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JAZF1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	JAZF1
Gene description	JAZF zinc finger 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB019271
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB019271

GENE INFORMATION
Gene name	JAZF1 (HGNC Symbol)
Synonyms	DKFZp761K2222, TIP27, ZNF802
Description	JAZF zinc finger 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband
Chromosome location (bp)	27830573 - 28180743
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153814 (version 83.38)
Entrez gene	221895
UniProt	Q86VZ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VZ6
Antibodypedia	JAZF1 antibodies

PROTEIN BROWSER

JAZF1-001	JAZF1-002	JAZF1-004	JAZF1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
JAZF1-001 ENSP00000283928 ENST00000283928	Q86VZ6 [Direct mapping] Juxtaposed with another zinc finger protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003676 [nucleic acid binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006629 [lipid metabolic process] GO:0017053 [transcriptional repressor complex] GO:0046872 [metal ion binding] Show all	243 aa 27.1 kDa	No	0
JAZF1-002 ENSP00000387976 ENST00000430432	C9JWY1 [Direct mapping] Juxtaposed with another zinc finger protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	173 aa 19.3 kDa	No	0
JAZF1-004 ENSP00000415096 ENST00000447620	C9JGY8 [Direct mapping] Juxtaposed with another zinc finger protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	181 aa 20.1 kDa	No	0
JAZF1-008 ENSP00000388302 ENST00000427814	H0Y403 [Direct mapping] Juxtaposed with another zinc finger protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	230 aa 25.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.