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CHD1

GENERAL INFORMATION

Gene name

 CHD1

Gene description

 Chromodomain helicase DNA binding protein 1

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA022236
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022236

GENE INFORMATION

Gene name

 CHD1

Synonyms

Description

 Chromodomain helicase DNA binding protein 1 (HGNC Symbol)

Entrez gene summary

 The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

Chromosome location (bp)

 98853985 - 98928957

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153922 (version 83.38)

Entrez gene

 1105

UniProt

 O14646 (UniProt - Evidence at protein level)

neXtProt

 NX_O14646

Antibodypedia

 CHD1 antibodies

PROTEIN BROWSER
CHD1-001
CHD1-008
CHD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHD1-001
ENSP00000483667
ENST00000614616
O14646 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 1
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032508 [DNA duplex unwinding]
GO:0035064 [methylated histone binding]
GO:0043923 [positive regulation by host of viral transcription]
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 1710 aa
196.7 kDa 		No 0
CHD1-008
ENSP00000479403
ENST00000511067
A0A087WVF4 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 272 aa
31.5 kDa 		No 0
CHD1-201
ENSP00000284049
ENST00000284049
O14646 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 1
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032508 [DNA duplex unwinding]
GO:0035064 [methylated histone binding]
GO:0043923 [positive regulation by host of viral transcription]
Show all
 1710 aa
196.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.