Cell atlas - CACNA2D1 - The Human Protein Atlas

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CACNA2D1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CACNA2D1
Gene description	Calcium channel, voltage-dependent, alpha 2/delta subunit 1
Protein class	FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SH-SY5Y, HUVEC TERT2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, HUVEC TERT2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CACNA2D1 (HGNC Symbol)
Synonyms	CACNA2, CACNL2A, LINC01112, lncRNA-N3, MHS3
Description	Calcium channel, voltage-dependent, alpha 2/delta subunit 1 (HGNC Symbol)
Entrez gene summary	The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
Chromosome	7
Cytoband	q21.11
Chromosome location (bp)	81946444 - 82443798
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153956 (version 83.38)
Entrez gene	781
UniProt	P54289 (UniProt - Evidence at protein level)
neXtProt	NX_P54289
Antibodypedia	CACNA2D1 antibodies

PROTEIN BROWSER

CACNA2D1-001	CACNA2D1-002	CACNA2D1-005	CACNA2D1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNA2D1-001 ENSP00000349320 ENST00000356860	P54289 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-1 Voltage-dependent calcium channel subunit alpha-2-1 Voltage-dependent calcium channel subunit delta-1 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005891 [voltage-gated calcium channel complex] GO:0006816 [calcium ion transport] GO:0016529 [sarcoplasmic reticulum] GO:0030315 [T-tubule] GO:0034765 [regulation of ion transmembrane transport] GO:0046872 [metal ion binding] GO:0051924 [regulation of calcium ion transport] GO:0070062 [extracellular exosome] GO:0070588 [calcium ion transmembrane transport] Show all	1091 aa 123.2 kDa	Yes	1
CACNA2D1-002 ENSP00000405395 ENST00000423588	E7ERK3 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0070588 [calcium ion transmembrane transport] Show all	309 aa 34.6 kDa	Yes	0
CACNA2D1-005 ENSP00000409374 ENST00000443883	H0Y715 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0070588 [calcium ion transmembrane transport] Show all	280 aa 32.4 kDa	No	0
CACNA2D1-201 ENSP00000348589 ENST00000356253	P54289 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-1 Voltage-dependent calcium channel subunit alpha-2-1 Voltage-dependent calcium channel subunit delta-1 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005246 [calcium channel regulator activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006816 [calcium ion transport] GO:0034765 [regulation of ion transmembrane transport] GO:0046872 [metal ion binding] GO:0051924 [regulation of calcium ion transport] GO:0070062 [extracellular exosome] GO:0070588 [calcium ion transmembrane transport] Show all	1103 aa 124.6 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.