Expression of UBASH3B in cancer - Summary

GENERAL INFORMATION
Gene name	UBASH3B
Gene description	Ubiquitin associated and SH3 domain containing B
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, HMC-1)
HPA (normal tissue):	Tissue enhanced (placenta, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues with highest expression levels in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA038605 , HPA038607
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA038605	HPA038607

GENE INFORMATION
Gene name	UBASH3B (HGNC Symbol)
Synonyms	KIAA1959, STS-1, TULA2
Description	Ubiquitin associated and SH3 domain containing B (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q24.1
Chromosome location (bp)	122655675 - 122814473
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154127 (version 83.38)
Entrez gene	84959
UniProt	Q8TF42 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TF42
Antibodypedia	UBASH3B antibodies

PROTEIN BROWSER

UBASH3B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBASH3B-001 ENSP00000284273 ENST00000284273	Q8TF42 [Direct mapping] Ubiquitin-associated and SH3 domain-containing protein B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006469 [negative regulation of protein kinase activity] GO:0009968 [negative regulation of signal transduction] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045670 [regulation of osteoclast differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0090331 [negative regulation of platelet aggregation] Show all	649 aa 72.7 kDa	No	0