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Ubiquitin associated and SH3 domain containing B (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Q8TF42 [Direct mapping] Ubiquitin-associated and SH3 domain-containing protein B
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006469 [negative regulation of protein kinase activity] GO:0009968 [negative regulation of signal transduction] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045670 [regulation of osteoclast differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0090331 [negative regulation of platelet aggregation]
