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LRRK1

GENERAL INFORMATION

Gene name

 LRRK1

Gene description

 Leucine-rich repeat kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (appendix)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues and in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA010537
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)

GENE INFORMATION

Gene name

 LRRK1 (HGNC Symbol)

Synonyms

 FLJ23119, KIAA1790, RIPK6, Roco1

Description

 Leucine-rich repeat kinase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q26.3

Chromosome location (bp)

 100919215 - 101078254

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154237 (version 83.38)

Entrez gene

 79705

UniProt

 Q38SD2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q38SD2

Antibodypedia

 LRRK1 antibodies

PROTEIN BROWSER
LRRK1-003
LRRK1-004
LRRK1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LRRK1-003
ENSP00000373600
ENST00000388948
Q38SD2 [Direct mapping]
Leucine-rich repeat serine/threonine-protein kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0036035 [osteoclast development]
GO:0042802 [identical protein binding]
GO:0045453 [bone resorption]
GO:0046872 [metal ion binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1902533 [positive regulation of intracellular signal transduction]
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 2015 aa
225.4 kDa 		No 0
LRRK1-004
ENSP00000433268
ENST00000532029
Q38SD2 [Direct mapping]
Leucine-rich repeat serine/threonine-protein kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0042802 [identical protein binding]
GO:0046872 [metal ion binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
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 264 aa
28.8 kDa 		No 0
LRRK1-007
ENSP00000435148
ENST00000534045
E9PLF8 [Direct mapping]
Leucine-rich repeat serine/threonine-protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 32 aa
3.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.