Expression of ABCA5 in cancer - Summary - The Human Protein Atlas

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ABCA5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABCA5
Gene description	ATP-binding cassette, sub-family A (ABC1), member 5
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SiHa)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA022032
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022032

GENE INFORMATION
Gene name	ABCA5 (HGNC Symbol)
Synonyms	EST90625
Description	ATP-binding cassette, sub-family A (ABC1), member 5 (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q24.3
Chromosome location (bp)	69244311 - 69327244
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154265 (version 83.38)
Entrez gene	23461
UniProt	Q8WWZ7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WWZ7
Antibodypedia	ABCA5 antibodies

PROTEIN BROWSER

ABCA5-001	ABCA5-003	ABCA5-004	ABCA5-008	ABCA5-009	ABCA5-011	ABCA5-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCA5-001 ENSP00000376443 ENST00000392676	Q8WWZ7 [Direct mapping] ATP-binding cassette sub-family A member 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0005794 [Golgi apparatus] GO:0006869 [lipid transport] GO:0008152 [metabolic process] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0031902 [late endosome membrane] GO:0033344 [cholesterol efflux] GO:0034375 [high-density lipoprotein particle remodeling] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0043691 [reverse cholesterol transport] GO:0055085 [transmembrane transport] Show all	1642 aa 186.5 kDa	No	>9
ABCA5-003 ENSP00000467448 ENST00000593153	K7EPM3 [Direct mapping] ATP-binding cassette sub-family A member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006869 [lipid transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	917 aa 103.6 kDa	No	9
ABCA5-004 ENSP00000467882 ENST00000588877	Q8WWZ7 [Direct mapping] ATP-binding cassette sub-family A member 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0006869 [lipid transport] GO:0008152 [metabolic process] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0031902 [late endosome membrane] GO:0033344 [cholesterol efflux] GO:0034375 [high-density lipoprotein particle remodeling] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0043691 [reverse cholesterol transport] GO:0055085 [transmembrane transport] Show all	1642 aa 186.5 kDa	No	>9
ABCA5-008 ENSP00000465351 ENST00000586811	K7EJW6 [Direct mapping] ATP-binding cassette sub-family A member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006869 [lipid transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	574 aa 65.6 kDa	No	5
ABCA5-009 ENSP00000467672 ENST00000588665	K7EQ50 [Direct mapping] ATP-binding cassette sub-family A member 5 Show all	Predicted intracellular proteins Show all	GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	38 aa 4.5 kDa	No	0
ABCA5-011 ENSP00000466662 ENST00000592568	K7EMV2 [Direct mapping] ATP-binding cassette sub-family A member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	127 aa 14.8 kDa	No	1
ABCA5-012 ENSP00000466931 ENST00000589975	K7ENF9 [Direct mapping] ATP-binding cassette sub-family A member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	192 aa 21.4 kDa	No	3

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The Human Protein Atlas

The Human Protein Atlas project is funded
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