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MMP21

GENERAL INFORMATION

Gene name

 MMP21

Gene description

 Matrix metallopeptidase 21

Protein class

 Enzymes
FDA approved drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (epididymis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MMP21

Synonyms

Description

 Matrix metallopeptidase 21 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]

Chromosome

 10

Cytoband

 q26.2

Chromosome location (bp)

 125766453 - 125775821

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154485 (version 83.38)

Entrez gene

 118856

UniProt

 Q8N119 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8N119

Antibodypedia

 MMP21 antibodies

PROTEIN BROWSER
MMP21-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP21-001
ENSP00000357798
ENST00000368808
Q8N119 [Direct mapping]
Matrix metalloproteinase-21
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Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0007368 [determination of left/right symmetry]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
GO:0060976 [coronary vasculature development]
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 569 aa
65 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.