Expression of PDLIM3 in cancer - Summary - The Human Protein Atlas

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PDLIM3

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDLIM3
Gene description	PDZ and LIM domain 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (LHCN-M2, U-266/70)
HPA (normal tissue):	Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in smooth and skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA004749
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), thyroid cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004749

GENE INFORMATION
Gene name	PDLIM3 (HGNC Symbol)
Synonyms	ALP
Description	PDZ and LIM domain 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]
Chromosome	4
Cytoband	q35.1
Chromosome location (bp)	185500660 - 185535612
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154553 (version 83.38)
Entrez gene	27295
UniProt	Q53GG5 (UniProt - Evidence at protein level)
neXtProt	NX_Q53GG5
Antibodypedia	PDLIM3 antibodies

PROTEIN BROWSER

PDLIM3-001	PDLIM3-002	PDLIM3-201	PDLIM3-202	PDLIM3-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDLIM3-001 ENSP00000284770 ENST00000284770	Q53GG5 [Direct mapping] PDZ and LIM domain protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007015 [actin filament organization] GO:0007507 [heart development] GO:0008092 [cytoskeletal protein binding] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0030018 [Z disc] Show all	364 aa 39.2 kDa	No	0
PDLIM3-002 ENSP00000284771 ENST00000284771	Q53GG5 [Direct mapping] PDZ and LIM domain protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0030018 [Z disc] Show all	316 aa 34.3 kDa	No	0
PDLIM3-201 ENSP00000284767 ENST00000284767	A0A0A0MQY0 [Direct mapping] PDZ and LIM domain protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	276 aa 30.2 kDa	No	0
PDLIM3-202 ENSP00000481771 ENST00000620787	A0A087WYF8 [Direct mapping] PDZ and LIM domain protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	197 aa 21.8 kDa	No	0
PDLIM3-203 ENSP00000486107 ENST00000629667	D6RAF1 [Direct mapping] PDZ and LIM domain protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 4.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.