Cell atlas - C21orf91 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	C21orf91
Gene description	Chromosome 21 open reading frame 91
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules. In addition localized to the cytokinetic bridge.
RNA cell category	Cell line enhanced (Karpas-707)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)
Additional location	In addition localized to the Cytokinetic bridge (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049030
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules. In addition localized to the cytokinetic bridge.

Main location

Microtubules (approved)

Additional location

Cytokinetic bridge (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA049030	A-431	Microtubules
HPA049030	U-2 OS	Microtubules
HPA049030	U-2 OS	Cytokinetic bridge	Intensity	Intensity
HPA049030	U-251 MG	Microtubules

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000022864 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049030	NIH 3T3	Microtubules

GENE INFORMATION
Gene name	C21orf91 (HGNC Symbol)
Synonyms	C21orf14, C21orf38, CSSG1, EURL, YG81
Description	Chromosome 21 open reading frame 91 (HGNC Symbol)
Entrez gene summary
Chromosome	21
Cytoband	q21.1
Chromosome location (bp)	17788967 - 17819386
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154642 (version 83.38)
Entrez gene	54149
UniProt	Q9NYK6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NYK6
Antibodypedia	C21orf91 antibodies

PROTEIN BROWSER

C21orf91-001	C21orf91-002	C21orf91-003	C21orf91-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C21orf91-001 ENSP00000383404 ENST00000400559	Q9NYK6 [Direct mapping] Protein EURL homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		296 aa 33.8 kDa	No	0
C21orf91-002 ENSP00000383403 ENST00000400558	Q9NYK6 [Direct mapping] Protein EURL homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		221 aa 25.4 kDa	No	0
C21orf91-003 ENSP00000284881 ENST00000284881	Q9NYK6 [Direct mapping] Protein EURL homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		297 aa 33.9 kDa	No	0
C21orf91-005 ENSP00000385566 ENST00000405964	E7ETB0 [Direct mapping] Protein EURL homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		242 aa 27.7 kDa	No	0