Cell atlas - NCAM2 - The Human Protein Atlas

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NCAM2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	NCAM2
Gene description	Neural cell adhesion molecule 2
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & nuclear bodies.
RNA cell category	Cell line enhanced (T-47d, WM-115)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved), Plasma membrane (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA030901
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, WM-115) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & nuclear bodies.

Main location

Nuclear bodies (approved), Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030901	HeLa	Nuclear bodies
	HPA030901	HeLa	Plasma membrane
	HPA030901	SH-SY5Y	Nuclear bodies
	HPA030901	SH-SY5Y	Plasma membrane	Intensity
	HPA030901	U-2 OS	Nuclear bodies
	HPA030901	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	NCAM2 (HGNC Symbol)
Synonyms	MGC51008, NCAM21
Description	Neural cell adhesion molecule 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q21.1
Chromosome location (bp)	20998315 - 21543329
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154654 (version 83.38)
Entrez gene	4685
UniProt	O15394 (UniProt - Evidence at protein level)
neXtProt	NX_O15394
Antibodypedia	NCAM2 antibodies

PROTEIN BROWSER

NCAM2-001	NCAM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCAM2-001 ENSP00000383392 ENST00000400546	O15394 [Direct mapping] Neural cell adhesion molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0016021 [integral component of membrane] GO:0030424 [axon] Show all	837 aa 93 kDa	Yes	2
NCAM2-201 ENSP00000284894 ENST00000284894	H9KV31 [Direct mapping] Neural cell adhesion molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] Show all	819 aa 91.1 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.