Expression of NCAM2 in cancer - Summary - The Human Protein Atlas

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NCAM2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NCAM2
Gene description	Neural cell adhesion molecule 2
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (T-47d, WM-115)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in the brain.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA030900
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030900

GENE INFORMATION
Gene name	NCAM2 (HGNC Symbol)
Synonyms	MGC51008, NCAM21
Description	Neural cell adhesion molecule 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q21.1
Chromosome location (bp)	20998315 - 21543329
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154654 (version 83.38)
Entrez gene	4685
UniProt	O15394 (UniProt - Evidence at protein level)
neXtProt	NX_O15394
Antibodypedia	NCAM2 antibodies

PROTEIN BROWSER

NCAM2-001	NCAM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCAM2-001 ENSP00000383392 ENST00000400546	O15394 [Direct mapping] Neural cell adhesion molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0016021 [integral component of membrane] GO:0030424 [axon] Show all	837 aa 93 kDa	Yes	2
NCAM2-201 ENSP00000284894 ENST00000284894	H9KV31 [Direct mapping] Neural cell adhesion molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] Show all	819 aa 91.1 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.