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ADAMTS1

GENERAL INFORMATION

Gene name

 ADAMTS1

Gene description

 ADAM metallopeptidase with thrombospondin type 1 motif, 1

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ)
HPA (normal tissue):Tissue enhanced (ovary)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a subset of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Uncertain based on 1 antibody.
CAB016394
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB016394

GENE INFORMATION

Gene name

 ADAMTS1 (HGNC Symbol)

Synonyms

 C3-C5, KIAA1346, METH1

Description

 ADAM metallopeptidase with thrombospondin type 1 motif, 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 26835747 - 26845409

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154734 (version 83.38)

Entrez gene

 9510

UniProt

 Q9UHI8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHI8

Antibodypedia

 ADAMTS1 antibodies

PROTEIN BROWSER
ADAMTS1-001
ADAMTS1-003
ADAMTS1-006
ADAMTS1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTS1-001
ENSP00000284984
ENST00000284984
Q9UHI8 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 1
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Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001542 [ovulation from ovarian follicle]
GO:0001822 [kidney development]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008201 [heparin binding]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010976 [positive regulation of neuron projection development]
GO:0030728 [ovulation]
GO:0031012 [extracellular matrix]
GO:0031410 [cytoplasmic vesicle]
GO:0044691 [tooth eruption]
GO:0060347 [heart trabecula formation]
GO:0071305 [cellular response to vitamin D]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
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 967 aa
105.4 kDa 		Yes 0
ADAMTS1-003
ENSP00000403404
ENST00000451462
H7C206 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
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 200 aa
22.3 kDa 		No 1
ADAMTS1-006
ENSP00000431065
ENST00000517452
E5RJR7 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
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 128 aa
14.6 kDa 		No 0
ADAMTS1-007
ENSP00000429557
ENST00000517777
E5RI60 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
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 171 aa
18.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.