Cell atlas - CXXC1 - The Human Protein Atlas

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CXXC1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS GFP

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CXXC1
Gene description	CXXC finger protein 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)
GFP	The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA044511
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044511	HEK 293	Nucleoplasm
	HPA044511	HeLa	Nucleus
	HPA044511	HeLa	Cytosol
	HPA044511	U-2 OS	No staining

GFP

Antibody	HPA044511
Validation	C-terminal tag BAC cell line: 2317 Validated: Antibody staining overlaps with GFP tagged protein


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	BAC id	Tag	Location antibody staining	Location tagged protein
	HPA044511	HeLa	2317	C-terminal	Nucleoplasm	Nucleoplasm
	HPA044511	HeLa	Normal	-	Nucleoplasm	-

GENE INFORMATION
Gene name	CXXC1 (HGNC Symbol)
Synonyms	CFP1, CGBP, hCGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1
Description	CXXC finger protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	50282343 - 50288304
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154832 (version 83.38)
Entrez gene	30827
UniProt	Q9P0U4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0U4
Antibodypedia	CXXC1 antibodies

PROTEIN BROWSER

CXXC1-001	CXXC1-002	CXXC1-004	CXXC1-017	CXXC1-018	CXXC1-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CXXC1-001 ENSP00000285106 ENST00000285106	Q9P0U4 [Direct mapping] CXXC-type zinc finger protein 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016607 [nuclear speck] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035097 [histone methyltransferase complex] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042800 [histone methyltransferase activity (H3-K4 specific)] GO:0044267 [cellular protein metabolic process] GO:0045322 [unmethylated CpG binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048188 [Set1C/COMPASS complex] GO:0051568 [histone H3-K4 methylation] Show all	656 aa 75.7 kDa	No	0
CXXC1-002 ENSP00000390475 ENST00000412036	Q9P0U4 [Direct mapping] CXXC-type zinc finger protein 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016363 [nuclear matrix] GO:0016607 [nuclear speck] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035097 [histone methyltransferase complex] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042800 [histone methyltransferase activity (H3-K4 specific)] GO:0044267 [cellular protein metabolic process] GO:0045322 [unmethylated CpG binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048188 [Set1C/COMPASS complex] GO:0051568 [histone H3-K4 methylation] Show all	660 aa 76.2 kDa	No	0
CXXC1-004 ENSP00000467634 ENST00000589940	K7EQ21 [Direct mapping] CXXC finger 1 (PHD domain), isoform CRA_c; CXXC-type zinc finger protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] Show all	613 aa 69.3 kDa	No	0
CXXC1-017 ENSP00000465849 ENST00000591474	K7EKZ6 [Direct mapping] CXXC-type zinc finger protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0008270 [zinc ion binding] Show all	250 aa 28.9 kDa	No	0
CXXC1-018 ENSP00000468038 ENST00000589548	K7EQZ1 [Direct mapping] CXXC-type zinc finger protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	253 aa 28.7 kDa	No	0
CXXC1-019 ENSP00000465284 ENST00000586837	K7EJR0 [Direct mapping] CXXC-type zinc finger protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	231 aa 26.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.