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CXXC1

GENERAL INFORMATION

Gene name

 CXXC1

Gene description

 CXXC finger protein 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044511
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and pancreatic cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044511

GENE INFORMATION

Gene name

 CXXC1 (HGNC Symbol)

Synonyms

 CFP1, CGBP, hCGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1

Description

 CXXC finger protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]

Chromosome

 18

Cytoband

 q21.1

Chromosome location (bp)

 50282343 - 50288304

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154832 (version 83.38)

Entrez gene

 30827

UniProt

 Q9P0U4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P0U4

Antibodypedia

 CXXC1 antibodies

PROTEIN BROWSER
CXXC1-001
CXXC1-002
CXXC1-004
CXXC1-017
CXXC1-018
CXXC1-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXXC1-001
ENSP00000285106
ENST00000285106
Q9P0U4 [Direct mapping]
CXXC-type zinc finger protein 1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016607 [nuclear speck]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035097 [histone methyltransferase complex]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0044267 [cellular protein metabolic process]
GO:0045322 [unmethylated CpG binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048188 [Set1C/COMPASS complex]
GO:0051568 [histone H3-K4 methylation]
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 656 aa
75.7 kDa 		No 0
CXXC1-002
ENSP00000390475
ENST00000412036
Q9P0U4 [Direct mapping]
CXXC-type zinc finger protein 1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035097 [histone methyltransferase complex]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0044267 [cellular protein metabolic process]
GO:0045322 [unmethylated CpG binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048188 [Set1C/COMPASS complex]
GO:0051568 [histone H3-K4 methylation]
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 660 aa
76.2 kDa 		No 0
CXXC1-004
ENSP00000467634
ENST00000589940
K7EQ21 [Direct mapping]
CXXC finger 1 (PHD domain), isoform CRA_c; CXXC-type zinc finger protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
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 613 aa
69.3 kDa 		No 0
CXXC1-017
ENSP00000465849
ENST00000591474
K7EKZ6 [Direct mapping]
CXXC-type zinc finger protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
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 250 aa
28.9 kDa 		No 0
CXXC1-018
ENSP00000468038
ENST00000589548
K7EQZ1 [Direct mapping]
CXXC-type zinc finger protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
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 253 aa
28.7 kDa 		No 0
CXXC1-019
ENSP00000465284
ENST00000586837
K7EJR0 [Direct mapping]
CXXC-type zinc finger protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
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 231 aa
26.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.