Expression of ACSS1 in cancer - Summary

GENERAL INFORMATION
Gene name	ACSS1
Gene description	Acyl-CoA synthetase short-chain family member 1
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RPMI-8226)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in several tissues, most abundant in placenta, kidney and testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA041014 , HPA043228
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable) and cervical cancer (favourable).
Lung cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041014	HPA043228

GENE INFORMATION
Gene name	ACSS1 (HGNC Symbol)
Synonyms	ACAS2L, AceCS2L, dJ568C11.3, MGC33843
Description	Acyl-CoA synthetase short-chain family member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	20
Cytoband	p11.21
Chromosome location (bp)	25006230 - 25058980
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154930 (version 83.38)
Entrez gene	84532
UniProt	Q9NUB1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NUB1
Antibodypedia	ACSS1 antibodies

PROTEIN BROWSER

ACSS1-001	ACSS1-002	ACSS1-201	ACSS1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSS1-001 ENSP00000316924 ENST00000323482	Q9NUB1 [Direct mapping] Acetyl-coenzyme A synthetase 2-like, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003987 [acetate-CoA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006069 [ethanol oxidation] GO:0006085 [acetyl-CoA biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0016208 [AMP binding] GO:0019413 [acetate biosynthetic process] GO:0019427 [acetyl-CoA biosynthetic process from acetate] GO:0019542 [propionate biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	689 aa 74.9 kDa	No	1
ACSS1-002 ENSP00000365916 ENST00000376726	Q5TF43 [Direct mapping] Acetyl-coenzyme A synthetase 2-like, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 16.1 kDa	No	0
ACSS1-201 ENSP00000388793 ENST00000432802	Q9NUB1 [Direct mapping] Acetyl-coenzyme A synthetase 2-like, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003987 [acetate-CoA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0006069 [ethanol oxidation] GO:0006085 [acetyl-CoA biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0016208 [AMP binding] GO:0019427 [acetyl-CoA biosynthetic process from acetate] GO:0044281 [small molecule metabolic process] Show all	575 aa 62.7 kDa	No	2
ACSS1-202 ENSP00000439304 ENST00000537502	Q9NUB1 [Direct mapping] Acetyl-coenzyme A synthetase 2-like, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003987 [acetate-CoA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0006069 [ethanol oxidation] GO:0006085 [acetyl-CoA biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0016208 [AMP binding] GO:0019427 [acetyl-CoA biosynthetic process from acetate] GO:0044281 [small molecule metabolic process] Show all	568 aa 62.7 kDa	No	2