Expression of APOOL in cancer - Summary - The Human Protein Atlas

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APOOL

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	APOOL
Gene description	Apolipoprotein O-like
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA000612
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000612

GENE INFORMATION
Gene name	APOOL (HGNC Symbol)
Synonyms	AAIR8193, CXorf33, FAM121A, Mic27, UNQ8193
Description	Apolipoprotein O-like (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	85003826 - 85093316
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155008 (version 83.38)
Entrez gene	139322
UniProt	Q6UXV4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXV4
Antibodypedia	APOOL antibodies

PROTEIN BROWSER

APOOL-001	APOOL-201	APOOL-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOOL-001 ENSP00000362268 ENST00000373173	Q6UXV4 [Direct mapping] MICOS complex subunit MIC27 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0061617 [MICOS complex] Show all	268 aa 29.2 kDa	Yes	0
APOOL-201 ENSP00000481770 ENST00000613473	A0A087WYF7 [Direct mapping] MICOS complex subunit MIC27 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		268 aa 29.2 kDa	Yes	0
APOOL-202 ENSP00000479012 ENST00000622540	A0A087WUX8 [Direct mapping] MICOS complex subunit MIC27 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		263 aa 28.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.