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NIFK

GENERAL INFORMATION

Gene name

 NIFK

Gene description

 Nucleolar protein interacting with the FHA domain of MKI67

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 5 antibodies.
HPA035735 , HPA035736 , CAB015382 , CAB075728 , CAB075729
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035735
HPA035736
CAB015382
CAB075728
CAB075729

GENE INFORMATION

Gene name

 NIFK (HGNC Symbol)

Synonyms

 hNIFK, MKI67IP, Nopp34

Description

 Nucleolar protein interacting with the FHA domain of MKI67 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]

Chromosome

 2

Cytoband

 q14.3

Chromosome location (bp)

 121726945 - 121736923

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155438 (version 83.38)

Entrez gene

 84365

UniProt

 Q9BYG3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYG3

Antibodypedia

 NIFK antibodies

PROTEIN BROWSER
NIFK-001
NIFK-004
NIFK-005
NIFK-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NIFK-001
ENSP00000285814
ENST00000285814
Q9BYG3 [Direct mapping]
MKI67 FHA domain-interacting nucleolar phosphoprotein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000794 [condensed nuclear chromosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006461 [protein complex assembly]
GO:0009303 [rRNA transcription]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016072 [rRNA metabolic process]
GO:0044822 [poly(A) RNA binding]
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 293 aa
34.2 kDa 		No 0
NIFK-004
ENSP00000398116
ENST00000451734
C9J6C5 [Direct mapping]
MKI67 FHA domain-interacting nucleolar phosphoprotein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
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 166 aa
19.6 kDa 		No 0
NIFK-005
ENSP00000406227
ENST00000447132
C9J808 [Direct mapping]
MKI67 FHA domain-interacting nucleolar phosphoprotein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005730 [nucleolus]
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 165 aa
19.5 kDa 		No 0
NIFK-007
ENSP00000390174
ENST00000423105
H7BZL0 [Direct mapping]
MKI67 FHA domain-interacting nucleolar phosphoprotein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 102 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.