Expression of SLC7A7 in cancer - Summary - The Human Protein Atlas

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SLC7A7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC7A7
Gene description	Solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (BEWO, CACO-2, EFO-21)
HPA (normal tissue):	Tissue enhanced (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036227
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036227

GENE INFORMATION
Gene name	SLC7A7 (HGNC Symbol)
Synonyms	LPI, y+LAT-1
Description	Solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	22773222 - 22829820
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155465 (version 83.38)
Entrez gene	9056
UniProt	Q9UM01 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UM01
Antibodypedia	SLC7A7 antibodies

PROTEIN BROWSER

SLC7A7-001	SLC7A7-002	SLC7A7-003	SLC7A7-005	SLC7A7-006	SLC7A7-007	SLC7A7-011	SLC7A7-014	SLC7A7-015	SLC7A7-017	SLC7A7-018	SLC7A7-019	SLC7A7-020	SLC7A7-021	SLC7A7-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC7A7-001 ENSP00000451881 ENST00000555702	Q9UM01 [Direct mapping] Y+L amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	511 aa 56 kDa	No	>9
SLC7A7-002 ENSP00000380666 ENST00000397532	Q9UM01 [Direct mapping] Y+L amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	511 aa 56 kDa	No	>9
SLC7A7-003 ENSP00000380663 ENST00000397529	Q9UM01 [Direct mapping] Y+L amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	511 aa 56 kDa	No	>9
SLC7A7-005 ENSP00000380662 ENST00000397528	Q9UM01 [Direct mapping] Y+L amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	511 aa 56 kDa	No	>9
SLC7A7-006 ENSP00000421554 ENST00000488800	D6RFE5 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	141 aa 14.8 kDa	No	3
SLC7A7-007 ENSP00000285850 ENST00000285850	Q9UM01 [Direct mapping] Y+L amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	511 aa 56 kDa	No	>9
SLC7A7-011 ENSP00000451026 ENST00000556350	H0YJ95 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	168 aa 18.4 kDa	No	3
SLC7A7-014 ENSP00000451063 ENST00000554741	G3V362 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	44 aa 4.6 kDa	No	0
SLC7A7-015 ENSP00000450495 ENST00000557629	G3V273 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	116 aa 12 kDa	No	2
SLC7A7-017 ENSP00000452083 ENST00000554517	G3V4Z6 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	245 aa 27.7 kDa	No	6
SLC7A7-018 ENSP00000450671 ENST00000554758	G3V2H8 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	164 aa 17.3 kDa	No	3
SLC7A7-019 ENSP00000451983 ENST00000555251	G3V4U1 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	122 aa 12.8 kDa	No	2
SLC7A7-020 ENSP00000452256 ENST00000555959	G3V5A1 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	30 aa 3.1 kDa	No	0
SLC7A7-021 ENSP00000452551 ENST00000555911	G3V5W2 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	115 aa 11.9 kDa	No	2
SLC7A7-022 ENSP00000450729 ENST00000557129	G3V2L0 [Direct mapping] Y+L amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000821 [regulation of arginine metabolic process] GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	106 aa 11 kDa	No	2

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The Human Protein Atlas

The Human Protein Atlas project is funded
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