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SLC7A7

GENERAL INFORMATION

Gene name

 SLC7A7

Gene description

 Solute carrier family 7 (amino acid transporter light chain, y+L system), member 7

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 15
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney)
GTEx:Group enriched (kidney, lung, small intestine, spleen, testis)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA036227
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, lung, small intestine, spleen, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC7A7 (HGNC Symbol)

Synonyms

 LPI, y+LAT-1

Description

 Solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 22773222 - 22829820

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155465 (version 83.38)

Entrez gene

 9056

UniProt

 Q9UM01 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UM01

Antibodypedia

 SLC7A7 antibodies

PROTEIN BROWSER
«
SLC7A7-001
SLC7A7-002
SLC7A7-003
SLC7A7-005
SLC7A7-006
SLC7A7-007
SLC7A7-011
SLC7A7-014
SLC7A7-015
SLC7A7-017
SLC7A7-018
SLC7A7-019
SLC7A7-020
SLC7A7-021
SLC7A7-022
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC7A7-001
ENSP00000451881
ENST00000555702
Q9UM01 [Direct mapping]
Y+L amino acid transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006520 [cellular amino acid metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0007596 [blood coagulation]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0050900 [leukocyte migration]
GO:0055085 [transmembrane transport]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 511 aa
56 kDa 		No >9
SLC7A7-002
ENSP00000380666
ENST00000397532
Q9UM01 [Direct mapping]
Y+L amino acid transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006520 [cellular amino acid metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0007596 [blood coagulation]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0050900 [leukocyte migration]
GO:0055085 [transmembrane transport]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 511 aa
56 kDa 		No >9
SLC7A7-003
ENSP00000380663
ENST00000397529
Q9UM01 [Direct mapping]
Y+L amino acid transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006520 [cellular amino acid metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0007596 [blood coagulation]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0050900 [leukocyte migration]
GO:0055085 [transmembrane transport]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 511 aa
56 kDa 		No >9
SLC7A7-005
ENSP00000380662
ENST00000397528
Q9UM01 [Direct mapping]
Y+L amino acid transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006520 [cellular amino acid metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0007596 [blood coagulation]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0050900 [leukocyte migration]
GO:0055085 [transmembrane transport]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 511 aa
56 kDa 		No >9
SLC7A7-006
ENSP00000421554
ENST00000488800
D6RFE5 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 141 aa
14.8 kDa 		No 3
SLC7A7-007
ENSP00000285850
ENST00000285850
Q9UM01 [Direct mapping]
Y+L amino acid transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006520 [cellular amino acid metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0007596 [blood coagulation]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0050900 [leukocyte migration]
GO:0055085 [transmembrane transport]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 511 aa
56 kDa 		No >9
SLC7A7-011
ENSP00000451026
ENST00000556350
H0YJ95 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 168 aa
18.4 kDa 		No 3
SLC7A7-014
ENSP00000451063
ENST00000554741
G3V362 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 44 aa
4.6 kDa 		No 0
SLC7A7-015
ENSP00000450495
ENST00000557629
G3V273 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 116 aa
12 kDa 		No 2
SLC7A7-017
ENSP00000452083
ENST00000554517
G3V4Z6 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 245 aa
27.7 kDa 		No 6
SLC7A7-018
ENSP00000450671
ENST00000554758
G3V2H8 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 164 aa
17.3 kDa 		No 3
SLC7A7-019
ENSP00000451983
ENST00000555251
G3V4U1 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 122 aa
12.8 kDa 		No 2
SLC7A7-020
ENSP00000452256
ENST00000555959
G3V5A1 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 30 aa
3.1 kDa 		No 0
SLC7A7-021
ENSP00000452551
ENST00000555911
G3V5W2 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 115 aa
11.9 kDa 		No 2
SLC7A7-022
ENSP00000450729
ENST00000557129
G3V2L0 [Direct mapping]
Y+L amino acid transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000821 [regulation of arginine metabolic process]
GO:0003333 [amino acid transmembrane transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015179 [L-amino acid transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015807 [L-amino acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:1902475 [L-alpha-amino acid transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
Show all
 106 aa
11 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.