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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADCY8
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADCY8

Gene description

Adenylate cyclase 8 (brain)

Protein class

Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (glioma, ovarian cancer, thyroid cancer)
HPA (cell line):Group enriched (U-138 MG, U-87 MG)
HPA (normal tissue):Group enriched (cerebral cortex, epididymis, fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA024291 , CAB018652
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (glioma, ovarian cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA024291
CAB018652

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues displayed weak staining or negative cells in most cases. Hepatocellular, colorectal, endometrial, prostate and pancreatic cancers displayed moderate cytoplasmic immunoreactivity in a majority of cases.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Colorectal malignancies exhibited strong cytoplasmic and membranous staining. Most malignant lymphomas and prostate cancers were negative. Most other malignancies showed weak to moderate staining.

GENE INFORMATION

Gene name

ADCY8 (HGNC Symbol)

Synonyms

AC8, ADCY3, HBAC1

Description

Adenylate cyclase 8 (brain) (HGNC Symbol)

Entrez gene summary

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q24.22

Chromosome location (bp)

130780301 - 131042426

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000155897 (version 83.38)

Entrez gene

114

UniProt

P40145 (UniProt - Evidence at protein level)

neXtProt

NX_P40145

Antibodypedia

ADCY8 antibodies

PROTEIN BROWSER

ADCY8-001
ADCY8-002
ADCY8-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADCY8-001
ENSP00000286355
ENST00000286355
P40145 [Direct mapping]
Adenylate cyclase type 8
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Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0004016 [adenylate cyclase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007611 [learning or memory]
GO:0007616 [long-term memory]
GO:0008294 [calcium- and calmodulin-responsive adenylate cyclase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019933 [cAMP-mediated signaling]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
Show all
1251 aa
140.1 kDa
No >9
ADCY8-002
ENSP00000367161
ENST00000377928
E7EVL1 [Direct mapping]
Adenylate cyclase type 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0000166 [nucleotide binding]
GO:0004016 [adenylate cyclase activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
1120 aa
125.2 kDa
No 8
ADCY8-003
ENSP00000428010
ENST00000522949
E5RFR2 [Direct mapping]
Adenylate cyclase type 8
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Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0005622 [intracellular]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
252 aa
29 kDa
No 0

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