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KIF5A

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GENERAL INFORMATION

Gene name

 KIF5A

Gene description

 Kinesin family member 5A

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & nucleoplasm. In addition localized to the mitotic spindle.

RNA cell category

 Cell line enhanced (SCLC-21H, HDLM-2, NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Cytosol (approved)

Additional location

 In addition localized to the Mitotic spindle (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA073448
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, HDLM-2, NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & nucleoplasm. In addition localized to the mitotic spindle.

Main location

 Nucleoplasm (approved), Cytosol (approved)

Additional location

 Mitotic spindle (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA073448 Hep G2 Nucleoplasm
Cytosol
HPA073448 SH-SY5Y Nucleoplasm
Mitotic spindle Intensity Intensity
Cytosol
HPA073448 U-2 OS Nucleoplasm
Plasma membrane

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

Intensity variation

 Mitotic spindle

GENE INFORMATION

Gene name

 KIF5A (HGNC Symbol)

Synonyms

 D12S1889, MY050, NKHC, SPG10

Description

 Kinesin family member 5A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 57549998 - 57586632

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155980 (version 83.38)

Entrez gene

 3798

UniProt

 Q12840 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12840

Antibodypedia

 KIF5A antibodies

PROTEIN BROWSER
KIF5A-001
KIF5A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF5A-001
ENSP00000408979
ENST00000455537
Q12840 [Direct mapping]
Kinesin heavy chain isoform 5A
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008104 [protein localization]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0048471 [perinuclear region of cytoplasm]
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 1032 aa
117.4 kDa 		No 0
KIF5A-002
ENSP00000286452
ENST00000286452
J3KNA1 [Direct mapping]
Kinesin-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008104 [protein localization]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0030705 [cytoskeleton-dependent intracellular transport]
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 943 aa
107.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.